DegronMD - Q9UHF7(TRPS1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T59M	TCGA-77-A5GB	LUSC	TCGA	PSSSS	DEG_SPOP_SBC_1	67:71	Mutation rewiring degron network	0.1111
p.D60Y	TCGA-80-5608	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	67:71	Mutation rewiring degron network	0.1389
p.D79Y	TCGA-AA-3510	COAD	TCGA	PSSSS	DEG_SPOP_SBC_1	67:71	Mutation rewiring degron network	0.1111
p.N68H	TCGA-DD-A73A	LIHC	TCGA	PSSSS	DEG_SPOP_SBC_1	67:71	Mutation altering degron motif	0.7423
p.N68K	TCGA-L9-A7SV	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	67:71	Mutation altering degron motif	0.6918
p.D70Y	DO7783	COAD	ICGC	PSSSS	DEG_SPOP_SBC_1	67:71	Mutation altering degron motif	0.7325
p.L80V	DO223025	ESCA	ICGC	PSSSS	DEG_SPOP_SBC_1	67:71	Mutation rewiring degron network	0.0833
p.S74G	DO233177	GACA	ICGC	PSSSS	DEG_SPOP_SBC_1	67:71	Mutation rewiring degron network	0.25
p.H67N	DO229041	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	67:71	Mutation altering degron motif	0.7423
p.N59K	DO49875	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	67:71	Mutation rewiring degron network	0.1111
p.L75F	DO23952	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	67:71	Mutation rewiring degron network	0.2222
p.K72T	DO47719	STAD	ICGC	PSSSS	DEG_SPOP_SBC_1	67:71	Mutation rewiring degron network	0.3056
p.N68S	SIDM00629	Breast Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	67:71	Mutation altering degron motif	0.7069
p.N68S	ACH-000573	Breast Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	67:71	Mutation altering degron motif	0.7069
p.N68S	MDA-MB-436	breast	COSMIC	PSSSS	DEG_SPOP_SBC_1	67:71	Mutation altering degron motif	0.7069
p.S81Y	SIDM00211	B-Lymphoblastic Leukemia	GDSC	PSSSS	DEG_SPOP_SBC_1	67:71	Mutation rewiring degron network	0.0556
p.S81Y	ACH-002209	Leukemia	CCLE	PSSSS	DEG_SPOP_SBC_1	67:71	Mutation rewiring degron network	0.0556
p.S81Y	ALL-PO	haematopoietic and lymphoid tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	67:71	Mutation rewiring degron network	0.0556
p.H76R	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	67:71	Mutation substituting flanking lysine	0.3056
p.H76R	SIDM01729	Endometrial Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	67:71	Mutation substituting flanking lysine	0.3056
p.H76R	ACH-000305	Esophageal Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	67:71	Mutation substituting flanking lysine	0.3056
p.H76R	ACH-000909	Endometrial/Uterine Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	67:71	Mutation substituting flanking lysine	0.3056
p.H76R	ACH-002038	Ovarian Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	67:71	Mutation substituting flanking lysine	0.3056
p.H76R	EC-GI-10	oesophagus	COSMIC	PSSSS	DEG_SPOP_SBC_1	67:71	Mutation substituting flanking lysine	0.3056
p.S68Y	ALL-PO	haematopoietic and lymphoid tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	67:71	Mutation altering degron motif	0.712
p.H63R	EC-GI-10	oesophagus	COSMIC	PSSSS	DEG_SPOP_SBC_1	67:71	Mutation rewiring degron network	0.2222
p.N59S	MDA-MB-436	breast	COSMIC	PSSSS	DEG_SPOP_SBC_1	67:71	Mutation rewiring degron network	0.1111
p.H67R	EC-GI-10	oesophagus	COSMIC	PSSSS	DEG_SPOP_SBC_1	67:71	Mutation altering degron motif	0.8244
p.S72Y	ALL-PO	haematopoietic and lymphoid tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	67:71	Mutation rewiring degron network	0.3056

Kaplan plot for TRPS1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRPS1

UniProt ID: Q9UHF7

Entrez ID: 7227

Protein name: Zinc finger transcription factor Trps1 (Tricho-rhino-phalangeal syndrome type I protein) (Zinc finger protein GC79)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TRPS1 in