DegronMD - Q9UHR6(ZNHIT2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A172T	TCGA-19-4068	GBM	TCGA	PARTPPDS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.1389
p.A172T	DO12028	GBM	ICGC	PARTPPDS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.1389
p.E155K	DO48394	BLCA	ICGC	PARTPPDS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.25
p.A151D	DO229009	LICA	ICGC	PARTPPDS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.1389
p.S165F	SIDM00303	Ovarian Carcinoma	GDSC	PARTPPDS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.7982
p.S165F	ACH-000584	Ovarian Cancer	CCLE	PARTPPDS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.7982
p.P158L	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	PARTPPDS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.6471
p.P158L	SIDM00060	Ovarian Carcinoma	GDSC	PARTPPDS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.6471
p.P158L	SIDM01045	Endometrial Carcinoma	GDSC	PARTPPDS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.6471
p.P158L	SIDM00970	Bladder Carcinoma	GDSC	PARTPPDS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.6471
p.P158L	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	PARTPPDS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.6471
p.P158L	SIDM01463	Endometrial Carcinoma	GDSC	PARTPPDS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.6471
p.P158L	SIDM01336	Glioblastoma	GDSC	PARTPPDS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.6471
p.P158L	SIDM01321	Pancreatic Carcinoma	GDSC	PARTPPDS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.6471
p.P158L	SIDM00959	Acute Myeloid Leukemia	GDSC	PARTPPDS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.6471
p.P158L	SIDM01619	Endometrial Carcinoma	GDSC	PARTPPDS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.6471
p.P158S	SIDM00333	Endometrial Carcinoma	GDSC	PARTPPDS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.6752
p.P158S	ACH-000988	Endometrial/Uterine Cancer	CCLE	PARTPPDS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.6752
p.D150N	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PARTPPDS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.1111
p.D150N	ACH-002222	Leukemia	CCLE	PARTPPDS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.1111
p.P174A	SIDM01611	Endometrial Carcinoma	GDSC	PARTPPDS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.0833
p.P174A	ACH-000996	Endometrial/Uterine Cancer	CCLE	PARTPPDS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.0833

Kaplan plot for ZNHIT2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNHIT2

UniProt ID: Q9UHR6

Entrez ID: 741

Protein name: Zinc finger HIT domain-containing protein 2 (Protein FON)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNHIT2 in