DegronMD - Q9UIS9(MBD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R404H	TCGA-04-1542	OV	TCGA	PPPY	ITCH	400:403	Mutation rewiring degron network	0.3056
p.R404H	DO31729	OV	ICGC	PPPY	ITCH	400:403	Mutation rewiring degron network	0.3056
p.R413L	TCGA-77-8154	LUSC	TCGA	PPPY	ITCH	400:403	Mutation rewiring degron network	0.0556
p.R413L	DO27224	LUSC	ICGC	PPPY	ITCH	400:403	Mutation rewiring degron network	0.0556
p.G396W	TCGA-D3-A2JC	SKCM	TCGA	PPPY	ITCH	400:403	Mutation rewiring degron network	0.2222
p.G396W	DO47578	SKCM	ICGC	PPPY	ITCH	400:403	Mutation rewiring degron network	0.2222
p.P409S	DO225120	BRCA	ICGC	PPPY	ITCH	400:403	Mutation rewiring degron network	0.1667
p.P409S	DO227903	BRCA	ICGC	PPPY	ITCH	400:403	Mutation rewiring degron network	0.1667
p.P401A	DO229013	COCA	ICGC	PPPY	ITCH	400:403	Mutation altering degron motif	0.7503
p.P401A	DO229005	COCA	ICGC	PPPY	ITCH	400:403	Mutation altering degron motif	0.7503
p.P401A	DO229505	LAML	ICGC	PPPY	ITCH	400:403	Mutation altering degron motif	0.7503
p.P401A	DO228947	LICA	ICGC	PPPY	ITCH	400:403	Mutation altering degron motif	0.7503
p.R406Q	ACH-000250	Kidney Cancer	CCLE	PPPY	ITCH	400:403	Mutation rewiring degron network	0.25
p.R398H	IGROV-1	ovary	COSMIC	PPPY	ITCH	400:403	Mutation rewiring degron network	0.2778
p.R409Q	PF-382	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	400:403	Mutation rewiring degron network	0.1667
p.S390G	Daudi	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	400:403	Mutation rewiring degron network	0.0556
p.R391Q	WM278	skin	COSMIC	PPPY	ITCH	400:403	Mutation blocking phosphorylation signal	0.5278
p.R400C	SNU-1040	large intestine	COSMIC	PPPY	ITCH	400:403	Mutation altering degron motif	0.8301

Kaplan plot for MBD1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MBD1

UniProt ID: Q9UIS9

Entrez ID: 4152

Protein name: Methyl-CpG-binding domain protein 1 (CXXC-type zinc finger protein 3) (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MBD1 in