DegronMD - Q9UJX2(CDC23)

FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:18485873}.

GO - Biological processes (BP): anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; metaphase/anaphase transition of mitotic cell cycle [GO:0007091]; mitotic cell cycle [GO:0000278]; mitotic metaphase plate congression [GO:0007080]; positive regulation of mitotic metaphase/anaphase tran... View more >>

GO - Molecular function (MF): ubiquitin-protein transferase activity [GO:0004842]

GO - Cellular component (CC): anaphase-promoting complex [GO:0005680]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
AASTS	DEG_SPOP_SBC_1	SPOP	Cell division cycle protein 23 homolog	2:6	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T5I	SIDM00513	Non-Small Cell Lung Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.8189
p.T5I	SIDM00342	T-Lymphoblastic Leukemia	GDSC	AASTS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.8189
p.T5I	SIDM01157	Other Solid Cancers	GDSC	AASTS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.8189
p.T5I	SIDM00927	Small Cell Lung Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.8189
p.T5I	SIDM01567	Hodgkin's Lymphoma	GDSC	AASTS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.8189
p.T5I	SIDM01768	Melanoma	GDSC	AASTS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.8189
p.M7V	TCGA-CD-A486	STAD	TCGA	AASTS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.3056
p.M7V	DO47853	STAD	ICGC	AASTS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.3056

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No drug screening data available for this protein.

No resistance data available for this Degron.

Kaplan plot for CDC23 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDC23

UniProt ID: Q9UJX2

Entrez ID: 8697

Protein name: Cell division cycle protein 23 homolog (Anaphase-promoting complex subunit 8) (APC8) (Cyclosome subunit 8)

External links: UniprotKB HGNC RefSeq COSMIC

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No drug screening data available for this protein.

No resistance data available for this Degron.

Kaplan plot for CDC23 in