FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2. {ECO:0000269|P...
FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2. {ECO:0000269|PubMed:23431138}.
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GO - Biological processes (BP):
apoptotic process [GO:0006915]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; ubiquitin-dependent protein catabolic process [GO:0006511]...
apoptotic process [GO:0006915]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; ubiquitin-dependent protein catabolic process [GO:0006511]
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GO - Molecular function (MF):
ubiquitin-protein transferase activity [GO:0004842]...
ubiquitin-protein transferase activity [GO:0004842]
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GO - Cellular component (CC):
cytoplasm [GO:0005737]; cytosol [GO:0005829]; ubiquitin ligase complex [GO:0000151]...
cytoplasm [GO:0005737]; cytosol [GO:0005829]; ubiquitin ligase complex [GO:0000151]
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