DegronMD - Q9UKN5(PRDM4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y90C	TCGA-AP-A051	UCEC	TCGA	PPPY	ITCH	94:97	Mutation rewiring degron network	0.2222
p.Y90C	DO42673	UCEC	ICGC	PPPY	ITCH	94:97	Mutation rewiring degron network	0.2222
p.R106T	TCGA-DK-A1A6	BLCA	TCGA	PPPY	ITCH	94:97	Mutation rewiring degron network	0.0833
p.R106T	DO472	BLCA	ICGC	PPPY	ITCH	94:97	Mutation rewiring degron network	0.0833
p.R88I	TCGA-E6-A1M0	UCEC	TCGA	PPPY	ITCH	94:97	Mutation rewiring degron network	0.1667
p.R88I	DO43682	UCEC	ICGC	PPPY	ITCH	94:97	Mutation rewiring degron network	0.1667
p.R88I	SIDM00345	Non-Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	94:97	Mutation rewiring degron network	0.1667
p.R88I	ACH-000627	Lung Cancer	CCLE	PPPY	ITCH	94:97	Mutation rewiring degron network	0.1667
p.R88I	LCLC-103H	lung	COSMIC	PPPY	ITCH	94:97	Mutation rewiring degron network	0.1667
p.S102N	TCGA-EO-A22X	UCEC	TCGA	PPPY	ITCH	94:97	Mutation rewiring degron network	0.1944
p.S102N	DO43907	UCEC	ICGC	PPPY	ITCH	94:97	Mutation rewiring degron network	0.1944
p.E101K	TCGA-QB-AA9O	SKCM	TCGA	PPPY	ITCH	94:97	Mutation rewiring degron network	0.2222
p.E101K	DO49427	PACA	ICGC	PPPY	ITCH	94:97	Mutation rewiring degron network	0.2222
p.E101K	DO51267	SKCM	ICGC	PPPY	ITCH	94:97	Mutation rewiring degron network	0.2222
p.P93H	DO228948	LICA	ICGC	PPPY	ITCH	94:97	Mutation rewiring degron network	0.3056
p.P94Q	DO229015	LICA	ICGC	PPPY	ITCH	94:97	Mutation altering degron motif	0.7035
p.E101Q	SIDM01757	Bladder Carcinoma	GDSC	PPPY	ITCH	94:97	Mutation rewiring degron network	0.2222
p.E101Q	ACH-000741	Bladder Cancer	CCLE	PPPY	ITCH	94:97	Mutation rewiring degron network	0.2222
p.F105V	SIDM01588	Endometrial Carcinoma	GDSC	PPPY	ITCH	94:97	Mutation rewiring degron network	0.1111
p.F105V	ACH-000993	Endometrial/Uterine Cancer	CCLE	PPPY	ITCH	94:97	Mutation rewiring degron network	0.1111

Kaplan plot for PRDM4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRDM4

UniProt ID: Q9UKN5

Entrez ID: 11108

Protein name: PR domain zinc finger protein 4 (EC 2.1.1.-) (PR domain-containing protein 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRDM4 in