DegronMD - Q9UKU9(ANGPTL2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R232H	TCGA-E6-A1LX	UCEC	TCGA	PPTY	ITCH	227:230	Mutation rewiring degron network	0.2778
p.R232H	DO41020	UCEC	ICGC	PPTY	ITCH	227:230	Mutation rewiring degron network	0.2778
p.R232H	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PPTY	ITCH	227:230	Mutation rewiring degron network	0.2778
p.R232H	SIDM00500	Colorectal Carcinoma	GDSC	PPTY	ITCH	227:230	Mutation rewiring degron network	0.2778
p.R232H	ACH-000929	Lung Cancer	CCLE	PPTY	ITCH	227:230	Mutation rewiring degron network	0.2778
p.R232H	ACH-000959	Colon/Colorectal Cancer	CCLE	PPTY	ITCH	227:230	Mutation rewiring degron network	0.2778
p.R232H	NCI-H2110	lung	COSMIC	PPTY	ITCH	227:230	Mutation rewiring degron network	0.2778
p.P227L	TCGA-EE-A2A6	SKCM	TCGA	PPTY	ITCH	227:230	Mutation altering degron motif	0.7582
p.P227L	DO37591	SKCM	ICGC	PPTY	ITCH	227:230	Mutation altering degron motif	0.7582
p.S238C	DO228246	BRCA	ICGC	PPTY	ITCH	227:230	Mutation rewiring degron network	0.1111
p.A219V	DO50970	LICA	ICGC	PPTY	ITCH	227:230	Mutation rewiring degron network	0.1111
p.Q236H	DO230968	LUSC	ICGC	PPTY	ITCH	227:230	Mutation rewiring degron network	0.1667
p.V224G	DO229257	THCA	ICGC	PPTY	ITCH	227:230	Mutation rewiring degron network	0.25
p.Y230C	SIDM00217	Colorectal Carcinoma	GDSC	PPTY	ITCH	227:230	Mutation altering degron motif	0.7087
p.Y230C	ACH-000999	Colon/Colorectal Cancer	CCLE	PPTY	ITCH	227:230	Mutation altering degron motif	0.7087
p.Y230C	SNU-1040	large intestine	COSMIC	PPTY	ITCH	227:230	Mutation altering degron motif	0.7087

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons