DegronMD - Q9UL40(ZNF346)

FUNCTION: Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity (PubMed:24521053). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:24521053, ECO:0000269|PubMed:28431233}.

GO - Biological processes (BP):

GO - Molecular function (MF): double-stranded RNA binding [GO:0003725]; enzyme binding [GO:0019899]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]

GO - Cellular component (CC): cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
PYSSS	DEG_SPOP_SBC_1	SPOP	Zinc finger protein 346	19:23	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G28S	SIDM01013	B-Cell Non-Hodgkin's Lymphoma	GDSC	PYSSS	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.1944
p.G28S	ACH-000106	Lymphoma	CCLE	PYSSS	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.1944
p.G33A	DO49145	PACA	ICGC	PYSSS	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.0556

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No resistance data available for this Degron.

Kaplan plot for ZNF346 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF346

UniProt ID: Q9UL40

Entrez ID: 23567

Protein name: Zinc finger protein 346 (Just another zinc finger protein)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for ZNF346 in