DegronMD - Q9ULJ7(ANKRD50)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1249Q	TCGA-09-2044	OV	TCGA	PSSTT	DEG_SPOP_SBC_1	1235:1239	Mutation rewiring degron network	0.0556
p.R1225H	TCGA-AX-A0J1	UCEC	TCGA	PSSTT	DEG_SPOP_SBC_1	1235:1239	Mutation rewiring degron network	0.0556
p.G1243E	TCGA-EE-A29M	SKCM	TCGA	PSSTT	DEG_SPOP_SBC_1	1235:1239	Mutation rewiring degron network	0.2222
p.E1236Q	DO44069	BLCA	ICGC	PSSTT	DEG_SPOP_SBC_1	1235:1239	Mutation altering degron motif	0.6744
p.F1242L	DO639	BLCA	ICGC	PSSTT	DEG_SPOP_SBC_1	1235:1239	Mutation rewiring degron network	0.25
p.P1249S	DO15623	HNSC	ICGC	PSSTT	DEG_SPOP_SBC_1	1235:1239	Mutation rewiring degron network	0.0556
p.P1249L	DO15623	HNSC	ICGC	PSSTT	DEG_SPOP_SBC_1	1235:1239	Mutation rewiring degron network	0.0556
p.I1235V	DO51806	LGG	ICGC	PSSTT	DEG_SPOP_SBC_1	1235:1239	Mutation altering degron motif	0.7076
p.D1239Y	DO26446	LUSC	ICGC	PSSTT	DEG_SPOP_SBC_1	1235:1239	Mutation altering degron motif	0.7325
p.P1249T	DO221122	MALY	ICGC	PSSTT	DEG_SPOP_SBC_1	1235:1239	Mutation rewiring degron network	0.0556
p.E1236K	DO37839	SKCM	ICGC	PSSTT	DEG_SPOP_SBC_1	1235:1239	Mutation altering degron motif	0.7022
p.S1238F	DO43795	UCEC	ICGC	PSSTT	DEG_SPOP_SBC_1	1235:1239	Mutation altering degron motif	0.7982
p.S1234F	SIDM00284	Melanoma	GDSC	PSSTT	DEG_SPOP_SBC_1	1235:1239	Mutation blocking phosphorylation signal	0.75
p.S1234F	ACH-000805	Skin Cancer	CCLE	PSSTT	DEG_SPOP_SBC_1	1235:1239	Mutation blocking phosphorylation signal	0.75
p.S1234F	COLO-679	skin	COSMIC	PSSTT	DEG_SPOP_SBC_1	1235:1239	Mutation blocking phosphorylation signal	0.75
p.S1234A	SIDM01725	Non-Cancerous	GDSC	PSSTT	DEG_SPOP_SBC_1	1235:1239	Mutation blocking phosphorylation signal	0.75
p.K1245T	LN-229	central nervous system	COSMIC	PSSTT	DEG_SPOP_SBC_1	1235:1239	Mutation rewiring degron network	0.1667

Kaplan plot for ANKRD50 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ANKRD50

UniProt ID: Q9ULJ7

Entrez ID: 57182

Protein name: Ankyrin repeat domain-containing protein 50

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ANKRD50 in