DegronMD - Q9ULK0(GRID1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P954R	TCGA-2F-A9KO	BLCA	TCGA	PLSSS	DEG_SPOP_SBC_1	954:958	Mutation altering degron motif	0.7512
p.P954R	DO51859	BLCA	ICGC	PLSSS	DEG_SPOP_SBC_1	954:958	Mutation altering degron motif	0.7512
p.L951V	TCGA-85-8481	LUSC	TCGA	PLSSS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.25
p.L951V	DO45465	LUSC	ICGC	PLSSS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.25
p.S963F	TCGA-D3-A8GL	SKCM	TCGA	PLSSS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.1944
p.S963F	TCGA-YD-A9TA	SKCM	TCGA	PLSSS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.1944
p.S963F	DO50287	SKCM	ICGC	PLSSS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.1944
p.S963F	DO219503	SKCM	ICGC	PLSSS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.1944
p.A959V	TCGA-DX-A2J0	SARC	TCGA	PLSSS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.3056
p.A959V	DO74	ALL	ICGC	PLSSS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.3056
p.A959V	DO219962	SARC	ICGC	PLSSS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.3056
p.G946W	TCGA-EB-A299	SKCM	TCGA	PLSSS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.1111
p.G946W	DO37794	SKCM	ICGC	PLSSS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.1111
p.C966G	TCGA-EO-A22R	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.1111
p.C966G	DO42713	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.1111
p.P962H	DO228246	BRCA	ICGC	PLSSS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.2222
p.N950K	DO228813	LICA	ICGC	PLSSS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.2222
p.H968N	DO229035	LICA	ICGC	PLSSS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.0556
p.P954L	DO227558	PACA	ICGC	PLSSS	DEG_SPOP_SBC_1	954:958	Mutation altering degron motif	0.7582
p.P954S	SIDM00217	Colorectal Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	954:958	Mutation altering degron motif	0.6752
p.P954S	SIDM01608	Endometrial Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	954:958	Mutation altering degron motif	0.6752
p.P954S	ACH-000990	Endometrial/Uterine Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	954:958	Mutation altering degron motif	0.6752
p.P954S	ACH-000999	Colon/Colorectal Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	954:958	Mutation altering degron motif	0.6752
p.P954S	SNU-1040	large intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	954:958	Mutation altering degron motif	0.6752
p.M964V	SIDM00986	Head and Neck Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.1667
p.M964V	ACH-000548	Head and Neck Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.1667
p.M964V	BHY	upper aerodigestive tract	COSMIC	PLSSS	DEG_SPOP_SBC_1	954:958	Mutation rewiring degron network	0.1667

Kaplan plot for GRID1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GRID1

UniProt ID: Q9ULK0

Entrez ID: 2894

Protein name: Glutamate receptor ionotropic, delta-1 (GluD1) (GluR delta-1 subunit)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GRID1 in