DegronMD - Q9UPE1(SRPK3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A325T	TCGA-06-0650	GBM	TCGA	PASSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.1667
p.P331S	TCGA-49-6743	LUAD	TCGA	PASSS	DEG_SPOP_SBC_1	331:335	Mutation altering degron motif	0.6752
p.S335Y	TCGA-64-1679	LUAD	TCGA	PASSS	DEG_SPOP_SBC_1	331:335	Mutation altering degron motif	0.712
p.P336H	TCGA-97-8179	LUAD	TCGA	PASSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.3056
p.S335F	TCGA-AC-A23H	BRCA	TCGA	PASSS	DEG_SPOP_SBC_1	331:335	Mutation altering degron motif	0.7982
p.G339W	TCGA-D3-A3CE	SKCM	TCGA	PASSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.2222
p.G341S	TCGA-DF-A2KN	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.1667
p.P338Q	TCGA-EE-A2M7	SKCM	TCGA	PASSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.25
p.P338L	TCGA-EO-A3KX	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.25
p.S334F	DO2401	BRCA	ICGC	PASSS	DEG_SPOP_SBC_1	331:335	Mutation altering degron motif	0.7982
p.A324T	DO12628	GBM	ICGC	PASSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.1389
p.P335H	DO25709	LUAD	ICGC	PASSS	DEG_SPOP_SBC_1	331:335	Mutation altering degron motif	0.7694
p.P330S	DO26092	LUAD	ICGC	PASSS	DEG_SPOP_SBC_1	331:335	Mutation blocking phosphorylation signal	0.75
p.S334Y	DO26200	LUAD	ICGC	PASSS	DEG_SPOP_SBC_1	331:335	Mutation altering degron motif	0.712
p.S333Y	DO233297	NACA	ICGC	PASSS	DEG_SPOP_SBC_1	331:335	Mutation altering degron motif	0.712
p.G340S	DO229465	SKCA	ICGC	PASSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.1944
p.G340S	DO223282	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.1944
p.G340D	DO229465	SKCA	ICGC	PASSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.1944
p.P337Q	DO37847	SKCM	ICGC	PASSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.2778
p.G338W	DO37405	SKCM	ICGC	PASSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.25
p.P337L	DO219774	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.2778
p.G340V	SIDM00087	Plasma Cell Myeloma	GDSC	PASSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.1944
p.G340V	SIDM00971	Breast Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.1944
p.G340V	SIDM00785	Acute Myeloid Leukemia	GDSC	PASSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.1944
p.G340V	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.1944
p.P322L	SIDM00002	Neuroblastoma	GDSC	PASSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.0833
p.A327T	SIDM00534	Colorectal Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.2222
p.A327T	HT-115	large intestine	COSMIC	PASSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.2222
p.A326T	HT-115	large intestine	COSMIC	PASSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.1944
p.R339Q	LNCaP-Clone-FGC	prostate	COSMIC	PASSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.2222
p.R340Q	LNCaP-Clone-FGC	prostate	COSMIC	PASSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.1944
p.N324H	HCC2998	large intestine	COSMIC	PASSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.1389
p.V341A	RL	haematopoietic and lymphoid tissue	COSMIC	PASSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.1667
p.R340H	PF-382	haematopoietic and lymphoid tissue	COSMIC	PASSS	DEG_SPOP_SBC_1	331:335	Mutation rewiring degron network	0.1944

Kaplan plot for SRPK3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SRPK3

UniProt ID: Q9UPE1

Entrez ID: 26576

Protein name: SRSF protein kinase 3 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1) (Serine/arginine-rich protein-specific kinase 3) (SR-protein-specific kinase 3) (Serine/threonine-protein kinase 23)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SRPK3 in