DegronMD - Q9UPG8(PLAGL2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S334F	TCGA-FW-A3R5	SKCM	TCGA	PPKY	ITCH	339:342	Mutation rewiring degron network	0.1944
p.S334F	DO37406	SKCM	ICGC	PPKY	ITCH	339:342	Mutation rewiring degron network	0.1944
p.S334F	SIDM01133	Other Solid Cancers	GDSC	PPKY	ITCH	339:342	Mutation rewiring degron network	0.1944
p.S334F	ACH-002177	Lung Cancer	CCLE	PPKY	ITCH	339:342	Mutation rewiring degron network	0.1944
p.S334F	NCI-H835	lung	COSMIC	PPKY	ITCH	339:342	Mutation rewiring degron network	0.1944
p.Y342H	SIDM00981	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPKY	ITCH	339:342	Mutation altering degron motif	0.7229
p.Y342H	ACH-000056	Lymphoma	CCLE	PPKY	ITCH	339:342	Mutation altering degron motif	0.7229
p.Y342H	DOHH-2	haematopoietic and lymphoid tissue	COSMIC	PPKY	ITCH	339:342	Mutation altering degron motif	0.7229
p.S334Y	SIDM01444	Glioblastoma	GDSC	PPKY	ITCH	339:342	Mutation rewiring degron network	0.1944
p.S334Y	ACH-000370	Brain Cancer	CCLE	PPKY	ITCH	339:342	Mutation rewiring degron network	0.1944
p.P335S	Daudi	haematopoietic and lymphoid tissue	COSMIC	PPKY	ITCH	339:342	Mutation rewiring degron network	0.2222

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons