DegronMD - Q9UQD0(SCN8A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L1890Q	TCGA-17-Z062	LUAD	TCGA	PITTT	DEG_SPOP_SBC_1	1885:1889	Mutation rewiring degron network	0.3056
p.R1892H	TCGA-2W-A8YY	CESC	TCGA	PITTT	DEG_SPOP_SBC_1	1885:1889	Mutation rewiring degron network	0.25
p.R1892H	TCGA-AA-3947	COAD	TCGA	PITTT	DEG_SPOP_SBC_1	1885:1889	Mutation rewiring degron network	0.25
p.R1892H	DO223732	CESC	ICGC	PITTT	DEG_SPOP_SBC_1	1885:1889	Mutation rewiring degron network	0.25
p.R1892H	DO8192	COAD	ICGC	PITTT	DEG_SPOP_SBC_1	1885:1889	Mutation rewiring degron network	0.25
p.R1892H	SIDM01019	Acute Myeloid Leukemia	GDSC	PITTT	DEG_SPOP_SBC_1	1885:1889	Mutation rewiring degron network	0.25
p.R1892H	ACH-002258	Leukemia	CCLE	PITTT	DEG_SPOP_SBC_1	1885:1889	Mutation rewiring degron network	0.25
p.R1892H	KMOE-2	haematopoietic and lymphoid tissue	COSMIC	PITTT	DEG_SPOP_SBC_1	1885:1889	Mutation rewiring degron network	0.25
p.P1885T	TCGA-37-5819	LUSC	TCGA	PITTT	DEG_SPOP_SBC_1	1885:1889	Mutation altering degron motif	0.7031
p.P1885T	DO26479	LUSC	ICGC	PITTT	DEG_SPOP_SBC_1	1885:1889	Mutation altering degron motif	0.7031
p.G467C	TCGA-AP-A1DK	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.1389
p.G467C	DO42033	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.1389
p.R1892C	TCGA-AP-A1E0	UCEC	TCGA	PITTT	DEG_SPOP_SBC_1	1885:1889	Mutation rewiring degron network	0.25
p.R1892C	TCGA-W5-AA36	CHOL	TCGA	PITTT	DEG_SPOP_SBC_1	1885:1889	Mutation rewiring degron network	0.25
p.R1892C	DO43154	UCEC	ICGC	PITTT	DEG_SPOP_SBC_1	1885:1889	Mutation rewiring degron network	0.25
p.R1892C	SIDM00545	Melanoma	GDSC	PITTT	DEG_SPOP_SBC_1	1885:1889	Mutation rewiring degron network	0.25
p.R1892C	ACH-000987	Skin Cancer	CCLE	PITTT	DEG_SPOP_SBC_1	1885:1889	Mutation rewiring degron network	0.25
p.R1892C	Mewo	skin	COSMIC	PITTT	DEG_SPOP_SBC_1	1885:1889	Mutation rewiring degron network	0.25
p.A1875T	TCGA-BG-A0VW	UCEC	TCGA	PITTT	DEG_SPOP_SBC_1	1885:1889	Mutation rewiring degron network	0.0556
p.A1875T	DO40843	UCEC	ICGC	PITTT	DEG_SPOP_SBC_1	1885:1889	Mutation rewiring degron network	0.0556
p.R475W	TCGA-BT-A3PH	BLCA	TCGA	PRSSS	DEG_SPOP_SBC_1	474:478	Mutation altering degron motif	0.7523
p.R475W	DO856	BLCA	ICGC	PRSSS	DEG_SPOP_SBC_1	474:478	Mutation altering degron motif	0.7523
p.E1884K	TCGA-D1-A16S	UCEC	TCGA	PITTT	DEG_SPOP_SBC_1	1885:1889	Mutation rewiring degron network	0.3056
p.E1884K	DO41596	UCEC	ICGC	PITTT	DEG_SPOP_SBC_1	1885:1889	Mutation rewiring degron network	0.3056
p.P1878S	TCGA-D3-A8GM	SKCM	TCGA	PITTT	DEG_SPOP_SBC_1	1885:1889	Mutation rewiring degron network	0.1389
p.P1878S	DO50288	SKCM	ICGC	PITTT	DEG_SPOP_SBC_1	1885:1889	Mutation rewiring degron network	0.1389
p.S1879F	TCGA-EE-A2MS	SKCM	TCGA	PITTT	DEG_SPOP_SBC_1	1885:1889	Mutation rewiring degron network	0.1667
p.S1879F	DO37567	SKCM	ICGC	PITTT	DEG_SPOP_SBC_1	1885:1889	Mutation rewiring degron network	0.1667
p.E468K	TCGA-ZJ-AAXI	CESC	TCGA	PRSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.1667
p.E468K	DO219756	CESC	ICGC	PRSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.1667
p.R1892L	DO222445	BTCA	ICGC	PITTT	DEG_SPOP_SBC_1	1885:1889	Mutation rewiring degron network	0.25
p.S478F	SIDM00850	Gastric Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	474:478	Mutation altering degron motif	0.9093
p.S478F	ACH-000880	Gastric Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	474:478	Mutation altering degron motif	0.9093
p.S478F	AGS	stomach	COSMIC	PRSSS	DEG_SPOP_SBC_1	474:478	Mutation altering degron motif	0.9093
p.P474R	ACH-001034	Bone Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	474:478	Mutation altering degron motif	0.7512
p.R1892G	ACH-001197	Lymphoma	CCLE	PITTT	DEG_SPOP_SBC_1	1885:1889	Mutation rewiring degron network	0.25
p.K1878N	LS-513	large intestine	COSMIC	PITTT	DEG_SPOP_SBC_1	1885:1889	Mutation rewiring degron network	0.1389
p.R1877W	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PITTT	DEG_SPOP_SBC_1	1885:1889	Mutation rewiring degron network	0.1111

Kaplan plot for SCN8A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SCN8A

UniProt ID: Q9UQD0

Entrez ID: 6334

Protein name: Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SCN8A in