DegronMD - Q9Y222(DMTF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R446C	TCGA-AA-3672	COAD	TCGA	AISSS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.1667
p.R446C	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.1667
p.R446C	ACH-000605	Esophageal Cancer	CCLE	AISSS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.1667
p.R446C	TE-6	oesophagus	COSMIC	AISSS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.1667
p.S454F	TCGA-CR-7368	HNSC	TCGA	AISSS	DEG_SPOP_SBC_1	452:456	Mutation altering degron motif	0.7982
p.R446H	TCGA-EO-A3AU	UCEC	TCGA	AISSS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.1667
p.R446H	SIDM00145	T-Lymphoblastic Leukemia	GDSC	AISSS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.1667
p.R446S	TCGA-ER-A19F	SKCM	TCGA	AISSS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.1667
p.A459T	TCGA-IB-7651	PAAD	TCGA	AISSS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.25
p.D444G	DO224569	BRCA	ICGC	AISSS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.1111
p.D444G	DO1005	BRCA	ICGC	AISSS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.1111
p.H465N	DO25416	LUAD	ICGC	AISSS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.0833
p.P453S	DO37410	SKCM	ICGC	AISSS	DEG_SPOP_SBC_1	452:456	Mutation altering degron motif	0.6752
p.D459Y	DO47407	SKCM	ICGC	AISSS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.25
p.A442V	DO47833	STAD	ICGC	AISSS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.0556
p.A445S	SIDM00845	Burkitt's Lymphoma	GDSC	AISSS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.1389
p.T454I	G-MEL	skin	COSMIC	AISSS	DEG_SPOP_SBC_1	452:456	Mutation altering degron motif	0.7078

Kaplan plot for DMTF1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DMTF1

UniProt ID: Q9Y222

Entrez ID: 9988

Protein name: Cyclin-D-binding Myb-like transcription factor 1 (hDMTF1) (Cyclin-D-interacting Myb-like protein 1) (hDMP1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DMTF1 in