DegronMD - Q9Y2C2(UST)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I389N	TCGA-50-5946	LUAD	TCGA	IPTPLET	DEG_SCF_FBW7_1	379:385	Mutation rewiring degron network	0.2222
p.I389N	DO24556	LUAD	ICGC	IPTPLET	DEG_SCF_FBW7_1	379:385	Mutation rewiring degron network	0.2222
p.P382L	TCGA-AA-A02R	COAD	TCGA	IPTPLET	DEG_SCF_FBW7_1	379:385	Mutation altering degron motif	0.7582
p.D390N	TCGA-AP-A1E0	UCEC	TCGA	IPTPLET	DEG_SCF_FBW7_1	379:385	Mutation rewiring degron network	0.1944
p.D390N	DO43154	UCEC	ICGC	IPTPLET	DEG_SCF_FBW7_1	379:385	Mutation rewiring degron network	0.1944
p.P388Q	TCGA-CN-6010	HNSC	TCGA	IPTPLET	DEG_SCF_FBW7_1	379:385	Mutation rewiring degron network	0.25
p.P388Q	DO14766	HNSC	ICGC	IPTPLET	DEG_SCF_FBW7_1	379:385	Mutation rewiring degron network	0.25
p.D390Y	TCGA-D3-A2J6	SKCM	TCGA	IPTPLET	DEG_SCF_FBW7_1	379:385	Mutation rewiring degron network	0.1944
p.D390Y	DO37901	SKCM	ICGC	IPTPLET	DEG_SCF_FBW7_1	379:385	Mutation rewiring degron network	0.1944
p.T385A	TCGA-F7-A61W	HNSC	TCGA	IPTPLET	DEG_SCF_FBW7_1	379:385	Mutation altering degron motif	0.7139
p.T385A	DO44434	HNSC	ICGC	IPTPLET	DEG_SCF_FBW7_1	379:385	Mutation altering degron motif	0.7139
p.L373M	TCGA-FS-A1ZR	SKCM	TCGA	IPTPLET	DEG_SCF_FBW7_1	379:385	Mutation rewiring degron network	0.1667
p.L373M	DO37651	SKCM	ICGC	IPTPLET	DEG_SCF_FBW7_1	379:385	Mutation rewiring degron network	0.1667
p.P372L	DO222427	BTCA	ICGC	IPTPLET	DEG_SCF_FBW7_1	379:385	Mutation rewiring degron network	0.1389
p.D391N	DO50332	ESAD	ICGC	IPTPLET	DEG_SCF_FBW7_1	379:385	Mutation rewiring degron network	0.1667
p.F377V	DO234363	ESAD	ICGC	IPTPLET	DEG_SCF_FBW7_1	379:385	Mutation rewiring degron network	0.2778
p.S369I	DO229031	LICA	ICGC	IPTPLET	DEG_SCF_FBW7_1	379:385	Mutation rewiring degron network	0.0556
p.D395Y	DO229035	LICA	ICGC	IPTPLET	DEG_SCF_FBW7_1	379:385	Mutation rewiring degron network	0.0556
p.P380L	ACH-001608	Brain Cancer	CCLE	IPTPLET	DEG_SCF_FBW7_1	379:385	Mutation altering degron motif	0.6471

Kaplan plot for UST in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UST

UniProt ID: Q9Y2C2

Entrez ID: 10090

Protein name: Uronyl 2-sulfotransferase (EC 2.8.2.-)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UST in