DegronMD - Q9Y2G1(MYRF)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P189L	TCGA-2Y-A9HA	LIHC	TCGA	PPHY	ITCH	195:198	Mutation rewiring degron network	0.1667
p.R86C	TCGA-BR-8363	STAD	TCGA	PPGY	ITCH	92:95	Mutation rewiring degron network	0.1667
p.R86C	DO47837	STAD	ICGC	PPGY	ITCH	92:95	Mutation rewiring degron network	0.1667
p.R86C	SIDM00596	Endometrial Carcinoma	GDSC	PPGY	ITCH	92:95	Mutation rewiring degron network	0.1667
p.R86C	SIDM00438	B-Lymphoblastic Leukemia	GDSC	PPGY	ITCH	92:95	Mutation rewiring degron network	0.1667
p.R86C	ACH-000941	Endometrial/Uterine Cancer	CCLE	PPGY	ITCH	92:95	Mutation rewiring degron network	0.1667
p.R86C	ACH-000954	Endometrial/Uterine Cancer	CCLE	PPGY	ITCH	92:95	Mutation rewiring degron network	0.1667
p.R86C	ACH-001517	Endometrial/Uterine Cancer	CCLE	PPGY	ITCH	92:95	Mutation rewiring degron network	0.1667
p.R86C	ACH-002275	Leukemia	CCLE	PPGY	ITCH	92:95	Mutation rewiring degron network	0.1667
p.R86C	HEC-1	endometrium	COSMIC	PPGY	ITCH	92:95	Mutation rewiring degron network	0.1667
p.R86C	MN-60	haematopoietic and lymphoid tissue	COSMIC	PPGY	ITCH	92:95	Mutation rewiring degron network	0.1667
p.R203W	TCGA-CA-5254	COAD	TCGA	PPHY	ITCH	195:198	Mutation rewiring degron network	0.1944
p.P89S	TCGA-EE-A182	SKCM	TCGA	PPGY	ITCH	92:95	Mutation rewiring degron network	0.25
p.P89S	DO37814	SKCM	ICGC	PPGY	ITCH	92:95	Mutation rewiring degron network	0.25
p.P93Q	TCGA-EE-A2MD	SKCM	TCGA	PPGY	ITCH	92:95	Mutation altering degron motif	0.7035
p.P93Q	DO37851	SKCM	ICGC	PPGY	ITCH	92:95	Mutation altering degron motif	0.7035
p.P91S	TCGA-EE-A2MH	SKCM	TCGA	PPGY	ITCH	92:95	Mutation rewiring degron network	0.3056
p.P91S	DO222628	MELA	ICGC	PPGY	ITCH	92:95	Mutation rewiring degron network	0.3056
p.P91S	DO37539	SKCM	ICGC	PPGY	ITCH	92:95	Mutation rewiring degron network	0.3056
p.P98Q	TCGA-ER-A19N	SKCM	TCGA	PPGY	ITCH	92:95	Mutation rewiring degron network	0.25
p.P98Q	DO37452	SKCM	ICGC	PPGY	ITCH	92:95	Mutation rewiring degron network	0.25
p.R103W	DO223732	CESC	ICGC	PPGY	ITCH	92:95	Mutation rewiring degron network	0.1111
p.A195V	DO10582	COAD	ICGC	PPHY	ITCH	195:198	Mutation altering degron motif	0.6936
p.R82Q	DO7918	COAD	ICGC	PPGY	ITCH	92:95	Mutation rewiring degron network	0.0556
p.R194W	DO8674	COAD	ICGC	PPHY	ITCH	195:198	Mutation rewiring degron network	0.3056
p.V185M	DO222503	COCA	ICGC	PPHY	ITCH	195:198	Mutation rewiring degron network	0.0556
p.R207W	DO234219	ESAD	ICGC	PPHY	ITCH	195:198	Mutation rewiring degron network	0.0833
p.D187N	DO234449	ESAD	ICGC	PPHY	ITCH	195:198	Mutation rewiring degron network	0.1111
p.Q95H	DO228978	LICA	ICGC	PPGY	ITCH	92:95	Mutation altering degron motif	0.7582
p.D195Y	DO229022	LICA	ICGC	PPHY	ITCH	195:198	Mutation altering degron motif	0.7325
p.G94V	DO229027	LICA	ICGC	PPGY	ITCH	92:95	Mutation altering degron motif	0.6421
p.D193Y	DO24790	LUAD	ICGC	PPHY	ITCH	195:198	Mutation rewiring degron network	0.2778
p.N188H	DO24682	LUAD	ICGC	PPHY	ITCH	195:198	Mutation rewiring degron network	0.1389
p.E185K	DO230965	LUSC	ICGC	PPHY	ITCH	195:198	Mutation rewiring degron network	0.0556
p.E185K	DO224599	LUSC	ICGC	PPHY	ITCH	195:198	Mutation rewiring degron network	0.0556
p.P89L	DO220877	MELA	ICGC	PPGY	ITCH	92:95	Mutation rewiring degron network	0.25
p.P89L	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PPGY	ITCH	92:95	Mutation rewiring degron network	0.25
p.S207L	DO50123	STAD	ICGC	PPHY	ITCH	195:198	Mutation rewiring degron network	0.0833
p.H199N	DO51783	STAD	ICGC	PPHY	ITCH	195:198	Mutation rewiring degron network	0.3056
p.Y189H	DO229275	THCA	ICGC	PPHY	ITCH	195:198	Mutation rewiring degron network	0.1667
p.R191Q	DO40867	UCEC	ICGC	PPHY	ITCH	195:198	Mutation rewiring degron network	0.2222
p.T88M	DO41871	UCEC	ICGC	PPGY	ITCH	92:95	Mutation rewiring degron network	0.2222
p.T88M	DO41235	UCEC	ICGC	PPGY	ITCH	92:95	Mutation rewiring degron network	0.2222
p.G96S	SIDM00216	Colorectal Carcinoma	GDSC	PPGY	ITCH	92:95	Mutation rewiring degron network	0.3056
p.G96S	ACH-000989	Colon/Colorectal Cancer	CCLE	PPGY	ITCH	92:95	Mutation rewiring degron network	0.3056
p.G96S	SNU-175	large intestine	COSMIC	PPGY	ITCH	92:95	Mutation rewiring degron network	0.3056
p.P98L	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PPGY	ITCH	92:95	Mutation rewiring degron network	0.25
p.P98L	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PPGY	ITCH	92:95	Mutation rewiring degron network	0.25
p.P98L	ACH-000995	Leukemia	CCLE	PPGY	ITCH	92:95	Mutation rewiring degron network	0.25
p.P98L	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PPGY	ITCH	92:95	Mutation rewiring degron network	0.25
p.P188L	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	PPHY	ITCH	195:198	Mutation rewiring degron network	0.1389
p.P188L	ACH-000693	Esophageal Cancer	CCLE	PPHY	ITCH	195:198	Mutation rewiring degron network	0.1389
p.G187V	ACH-000858	Lung Cancer	CCLE	PPHY	ITCH	195:198	Mutation rewiring degron network	0.1111
p.V197M	OS-RC-2	kidney	COSMIC	PPHY	ITCH	195:198	Mutation altering degron motif	0.7208
p.V197M	MKN1	stomach	COSMIC	PPHY	ITCH	195:198	Mutation altering degron motif	0.7208
p.D190A	EMC-BAC-1	lung	COSMIC	PPHY	ITCH	195:198	Mutation rewiring degron network	0.1944
p.A101T	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PPGY	ITCH	92:95	Mutation rewiring degron network	0.1667
p.G87S	SNU-175	large intestine	COSMIC	PPGY	ITCH	92:95	Mutation rewiring degron network	0.1944

Kaplan plot for MYRF in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYRF

UniProt ID: Q9Y2G1

Entrez ID: 745

Protein name: Myelin regulatory factor (EC 3.4.-.-) (Myelin gene regulatory factor) [Cleaved into: Myelin regulatory factor, N-terminal; Myelin regulatory factor, C-terminal]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYRF in