DegronMD - Q9Y2G4(ANKRD6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P645L	TCGA-A5-A0R8	UCEC	TCGA	AASST	DEG_SPOP_SBC_1	637:641	Mutation rewiring degron network	0.2222
p.P645L	TCGA-BG-A220	UCEC	TCGA	AASST	DEG_SPOP_SBC_1	637:641	Mutation rewiring degron network	0.2222
p.G650D	TCGA-EO-A3B0	UCEC	TCGA	AASST	DEG_SPOP_SBC_1	637:641	Mutation rewiring degron network	0.0833
p.A637T	TCGA-EO-A3KX	UCEC	TCGA	AASST	DEG_SPOP_SBC_1	637:641	Mutation altering degron motif	0.7139
p.A637T	SIDM01165	Pancreatic Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	637:641	Mutation altering degron motif	0.7139
p.A637T	ACH-000155	Pancreatic Cancer	CCLE	AASST	DEG_SPOP_SBC_1	637:641	Mutation altering degron motif	0.7139
p.A637T	SW1990	pancreas	COSMIC	AASST	DEG_SPOP_SBC_1	637:641	Mutation altering degron motif	0.7139
p.R632H	TCGA-G4-6309	COAD	TCGA	AASST	DEG_SPOP_SBC_1	637:641	Mutation rewiring degron network	0.1944
p.R632H	SIDM00699	Small Cell Lung Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	637:641	Mutation rewiring degron network	0.1944
p.R632H	NCI-H2141	lung	COSMIC	AASST	DEG_SPOP_SBC_1	637:641	Mutation rewiring degron network	0.1944
p.P628L	TCGA-UY-A9PF	BLCA	TCGA	AASST	DEG_SPOP_SBC_1	637:641	Mutation rewiring degron network	0.0833
p.L632R	DO8018	COAD	ICGC	AASST	DEG_SPOP_SBC_1	637:641	Mutation rewiring degron network	0.1944
p.Q634K	DO37921	SKCM	ICGC	AASST	DEG_SPOP_SBC_1	637:641	Mutation rewiring degron network	0.25
p.A639T	DO38495	STAD	ICGC	AASST	DEG_SPOP_SBC_1	637:641	Mutation altering degron motif	0.7139
p.T649R	SIDM01117	Small Cell Lung Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	637:641	Mutation rewiring degron network	0.1111
p.T629K	SIDM00327	Hodgkin's Lymphoma	GDSC	AASST	DEG_SPOP_SBC_1	637:641	Mutation rewiring degron network	0.1111
p.T629K	ACH-000754	Lymphoma	CCLE	AASST	DEG_SPOP_SBC_1	637:641	Mutation rewiring degron network	0.1111
p.T629K	L-428	haematopoietic and lymphoid tissue	COSMIC	AASST	DEG_SPOP_SBC_1	637:641	Mutation rewiring degron network	0.1111
p.S639G	SIDM00808	Burkitt's Lymphoma	GDSC	AASST	DEG_SPOP_SBC_1	637:641	Mutation altering degron motif	0.6993
p.S639G	SIDM01254	Burkitt's Lymphoma	GDSC	AASST	DEG_SPOP_SBC_1	637:641	Mutation altering degron motif	0.6993
p.A632T	SW1990	pancreas	COSMIC	AASST	DEG_SPOP_SBC_1	637:641	Mutation rewiring degron network	0.1944
p.K651R	DU-145	prostate	COSMIC	AASST	DEG_SPOP_SBC_1	637:641	Mutation rewiring degron network	0.0556
p.R627H	NCI-H2141	lung	COSMIC	AASST	DEG_SPOP_SBC_1	637:641	Mutation rewiring degron network	0.0556

Kaplan plot for ANKRD6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ANKRD6

UniProt ID: Q9Y2G4

Entrez ID: 22881

Protein name: Ankyrin repeat domain-containing protein 6 (Diversin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ANKRD6 in