DegronMD - Q9Y2J4(AMOTL2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G727V	TCGA-AA-A022	COAD	TCGA	PDSTS	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.1389
p.P743S	TCGA-AP-A0LE	UCEC	TCGA	PDSTS	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.1944
p.P210Q	TCGA-C5-A901	CESC	TCGA	PPQY	ITCH	210:213	Mutation altering degron motif	0.7035
p.P210Q	DO49914	CESC	ICGC	PPQY	ITCH	210:213	Mutation altering degron motif	0.7035
p.Q212E	TCGA-CQ-A4CD	HNSC	TCGA	PPQY	ITCH	210:213	Mutation altering degron motif	0.5633
p.Q212E	DO49038	HNSC	ICGC	PPQY	ITCH	210:213	Mutation altering degron motif	0.5633
p.D747H	TCGA-DG-A2KM	CESC	TCGA	PDSTS	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.0833
p.R207L	TCGA-ER-A19P	SKCM	TCGA	PPQY	ITCH	210:213	Mutation rewiring degron network	0.25
p.R207L	DO47623	SKCM	ICGC	PPQY	ITCH	210:213	Mutation rewiring degron network	0.25
p.D744H	DO51597	CESC	ICGC	PDSTS	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.1667
p.G726V	DO10647	COAD	ICGC	PDSTS	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.1111
p.E729D	DO229010	COCA	ICGC	PDSTS	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.1944
p.E729D	DO229013	COCA	ICGC	PDSTS	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.1944
p.E729D	DO229016	COCA	ICGC	PDSTS	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.1944
p.E729D	DO229003	COCA	ICGC	PDSTS	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.1944
p.E729D	DO229005	COCA	ICGC	PDSTS	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.1944
p.T223N	DO229018	LICA	ICGC	PPQY	ITCH	210:213	Mutation rewiring degron network	0.0556
p.D746E	DO229029	LICA	ICGC	PDSTS	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.1111
p.P209T	DO229022	LICA	ICGC	PPQY	ITCH	210:213	Mutation rewiring degron network	0.3056
p.P209T	DO229041	LICA	ICGC	PPQY	ITCH	210:213	Mutation rewiring degron network	0.3056
p.P740S	DO43418	UCEC	ICGC	PDSTS	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.2778
p.G739C	SIDM01123	Prostate Carcinoma	GDSC	PDSTS	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.3056
p.G739C	ACH-000177	Prostate Cancer	CCLE	PDSTS	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.3056
p.G739C	NCI-H660	prostate	COSMIC	PDSTS	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.3056
p.A735T	SIDM00422	Hodgkin's Lymphoma	GDSC	PDSTS	DEG_SPOP_SBC_1	734:738	Mutation altering degron motif	0.7139
p.A735T	ACH-001203	Lymphoma	CCLE	PDSTS	DEG_SPOP_SBC_1	734:738	Mutation altering degron motif	0.7139
p.A735T	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	PDSTS	DEG_SPOP_SBC_1	734:738	Mutation altering degron motif	0.7139
p.R214C	SIDM00781	Colorectal Carcinoma	GDSC	PPQY	ITCH	210:213	Mutation rewiring degron network	0.3056
p.R214C	SIDM00780	Colorectal Carcinoma	GDSC	PPQY	ITCH	210:213	Mutation rewiring degron network	0.3056
p.R214C	ACH-000967	Colon/Colorectal Cancer	CCLE	PPQY	ITCH	210:213	Mutation rewiring degron network	0.3056
p.S725L	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PDSTS	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.0833
p.S725L	ACH-002256	Leukemia	CCLE	PDSTS	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.0833
p.S725L	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PDSTS	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.0833
p.R219G	SIDM01617	Endometrial Carcinoma	GDSC	PPQY	ITCH	210:213	Mutation rewiring degron network	0.1667
p.R219G	ACH-000994	Endometrial/Uterine Cancer	CCLE	PPQY	ITCH	210:213	Mutation rewiring degron network	0.1667
p.R748Q	SIDM01443	Gastric Carcinoma	GDSC	PDSTS	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.0556
p.V729A	ACH-001518	Endometrial/Uterine Cancer	CCLE	PDSTS	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.1944
p.P204L	NCI-H1581	lung	COSMIC	PPQY	ITCH	210:213	Mutation rewiring degron network	0.1667
p.G208A	ESO51	oesophagus	COSMIC	PPQY	ITCH	210:213	Mutation rewiring degron network	0.2778
p.P735Q	RPMI-8226	haematopoietic and lymphoid tissue	COSMIC	PDSTS	DEG_SPOP_SBC_1	734:738	Mutation altering degron motif	0.7035
p.P732Q	RPMI-8226	haematopoietic and lymphoid tissue	COSMIC	PDSTS	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.2778
p.P734Q	RPMI-8226	haematopoietic and lymphoid tissue	COSMIC	PDSTS	DEG_SPOP_SBC_1	734:738	Mutation altering degron motif	0.7035

Kaplan plot for AMOTL2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AMOTL2

UniProt ID: Q9Y2J4

Entrez ID: 51421

Protein name: Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AMOTL2 in