DegronMD - Q9Y2K6(USP20)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R376Q	TCGA-AX-A3FT	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.25
p.R376Q	DO40801	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.25
p.P374S	TCGA-EE-A3JE	SKCM	TCGA	PRSSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.3056
p.P374S	DO48766	SKCM	ICGC	PRSSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.3056
p.P374L	TCGA-EE-A3JE	SKCM	TCGA	PRSSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.3056
p.P374L	DO48766	SKCM	ICGC	PRSSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.3056
p.P367Q	TCGA-N7-A4Y0	UCS	TCGA	PRSSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.2778
p.P367Q	SIDM00792	Small Cell Lung Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.2778
p.P367Q	ACH-002170	Lung Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.2778
p.D359H	DO222839	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.0556
p.D359H	DO229213	THCA	ICGC	PRSSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.0556
p.D359E	DO222839	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.0556
p.A362V	DO233708	GACA	ICGC	PRSSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.1389
p.P367S	DO232826	NACA	ICGC	PRSSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.2778
p.P366T	DO232832	NACA	ICGC	PRSSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.25
p.Q365K	DO229221	THCA	ICGC	PRSSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.2222
p.P367L	SIDM00373	Endometrial Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.2778
p.P367L	ACH-000974	Endometrial/Uterine Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.2778
p.P367L	ACH-002026	Endometrial/Uterine Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.2778
p.P361S	SIDM00502	B-Lymphoblastic Leukemia	GDSC	PRSSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.1111
p.P361S	ACH-000157	Lymphoma	CCLE	PRSSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.1111
p.P361S	ACH-001060	Lymphoma	CCLE	PRSSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.1111
p.T377M	SIDM00793	Burkitt's Lymphoma	GDSC	PRSSS	DEG_SPOP_SBC_1	369:373	Mutation blocking phosphorylation signal	0.6667
p.T377M	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PRSSS	DEG_SPOP_SBC_1	369:373	Mutation blocking phosphorylation signal	0.6667
p.T377M	ACH-002222	Leukemia	CCLE	PRSSS	DEG_SPOP_SBC_1	369:373	Mutation blocking phosphorylation signal	0.6667
p.T377M	ACH-002236	Lymphoma	CCLE	PRSSS	DEG_SPOP_SBC_1	369:373	Mutation blocking phosphorylation signal	0.6667

Kaplan plot for USP20 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

USP20

UniProt ID: Q9Y2K6

Entrez ID: 10868

Protein name: Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (VHL-interacting deubiquitinating enzyme 2) (hVDU2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for USP20 in