DegronMD - Q9Y2L5(TRAPPC8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1129R	TCGA-CS-6665	LGG	TCGA	VSSSS	DEG_SPOP_SBC_1	1125:1129	Mutation altering degron motif	0.7427
p.S1129R	TCGA-X6-A7WA	SARC	TCGA	VSSSS	DEG_SPOP_SBC_1	1125:1129	Mutation altering degron motif	0.7427
p.S1118F	DO9876	COAD	ICGC	VSSSS	DEG_SPOP_SBC_1	1125:1129	Mutation substituting flanking lysine	0.25
p.S1136R	DO41758	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	1125:1129	Mutation blocking ubiquitination signal	0.5833
p.V1117I	SIDM01314	Colorectal Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	1125:1129	Mutation rewiring degron network	0.1111
p.I1122V	SIDM00845	Burkitt's Lymphoma	GDSC	VSSSS	DEG_SPOP_SBC_1	1125:1129	Mutation rewiring degron network	0.25
p.I1122V	SIDM00846	Cervical Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	1125:1129	Mutation rewiring degron network	0.25
p.Y1122C	QGP-1	pancreas	COSMIC	VSSSS	DEG_SPOP_SBC_1	1125:1129	Mutation rewiring degron network	0.25

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons