DegronMD - Q9Y448(KNSTRN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A41T	TCGA-06-5416	GBM	TCGA	PPSY	ITCH	28:31	Mutation rewiring degron network	0.0556
p.A41T	DO10880	GBM	ICGC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.0556
p.A41T	SIDM01608	Endometrial Carcinoma	GDSC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.0556
p.A41T	ACH-000990	Endometrial/Uterine Cancer	CCLE	PPSY	ITCH	28:31	Mutation rewiring degron network	0.0556
p.C22Y	TCGA-44-7670	LUAD	TCGA	PPSY	ITCH	28:31	Mutation rewiring degron network	0.1667
p.C22Y	TCGA-53-A4EZ	LUAD	TCGA	PPSY	ITCH	28:31	Mutation rewiring degron network	0.1667
p.C22Y	DO45319	LUAD	ICGC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.1667
p.C22Y	DO23555	LUAD	ICGC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.1667
p.D23Y	TCGA-49-AAR0	LUAD	TCGA	PPSY	ITCH	28:31	Mutation rewiring degron network	0.1944
p.D23Y	DO218917	LUAD	ICGC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.1944
p.R32Q	TCGA-A5-A0G2	UCEC	TCGA	PPSY	ITCH	28:31	Mutation rewiring degron network	0.3056
p.R32Q	TCGA-EE-A2M5	SKCM	TCGA	PPSY	ITCH	28:31	Mutation rewiring degron network	0.3056
p.R32Q	DO37425	SKCM	ICGC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.3056
p.R32Q	DO41235	UCEC	ICGC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.3056
p.P26Q	TCGA-A5-A2K5	UCEC	TCGA	PPSY	ITCH	28:31	Mutation rewiring degron network	0.2778
p.P26Q	DO41379	UCEC	ICGC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.2778
p.H25R	TCGA-AA-3815	COAD	TCGA	PPSY	ITCH	28:31	Mutation rewiring degron network	0.25
p.H25R	DO9924	COAD	ICGC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.25
p.D23V	TCGA-AR-A256	BRCA	TCGA	PPSY	ITCH	28:31	Mutation rewiring degron network	0.1944
p.D23V	DO4155	BRCA	ICGC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.1944
p.D23N	TCGA-BF-AAP4	SKCM	TCGA	PPSY	ITCH	28:31	Mutation rewiring degron network	0.1944
p.D23N	TCGA-CV-7568	HNSC	TCGA	PPSY	ITCH	28:31	Mutation rewiring degron network	0.1944
p.D23N	TCGA-DF-A2KU	UCEC	TCGA	PPSY	ITCH	28:31	Mutation rewiring degron network	0.1944
p.D23N	DO14160	HNSC	ICGC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.1944
p.D23N	DO219468	SKCM	ICGC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.1944
p.D23N	DO223286	UCEC	ICGC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.1944
p.P28S	TCGA-D3-A2JD	SKCM	TCGA	PPSY	ITCH	28:31	Mutation altering degron motif	0.6752
p.P28S	TCGA-EE-A2MP	SKCM	TCGA	PPSY	ITCH	28:31	Mutation altering degron motif	0.6752
p.P28S	DO37543	SKCM	ICGC	PPSY	ITCH	28:31	Mutation altering degron motif	0.6752
p.P28S	DO37818	SKCM	ICGC	PPSY	ITCH	28:31	Mutation altering degron motif	0.6752
p.P28L	TCGA-D3-A2JD	SKCM	TCGA	PPSY	ITCH	28:31	Mutation altering degron motif	0.7582
p.P28L	TCGA-EE-A29G	SKCM	TCGA	PPSY	ITCH	28:31	Mutation altering degron motif	0.7582
p.P28L	DO37543	SKCM	ICGC	PPSY	ITCH	28:31	Mutation altering degron motif	0.7582
p.P28L	DO47303	SKCM	ICGC	PPSY	ITCH	28:31	Mutation altering degron motif	0.7582
p.S24F	TCGA-D3-A8GI	SKCM	TCGA	PPSY	ITCH	28:31	Mutation rewiring degron network	0.2222
p.S24F	TCGA-DA-A1IC	SKCM	TCGA	PPSY	ITCH	28:31	Mutation rewiring degron network	0.2222
p.S24F	TCGA-EE-A181	SKCM	TCGA	PPSY	ITCH	28:31	Mutation rewiring degron network	0.2222
p.S24F	TCGA-EE-A3AH	SKCM	TCGA	PPSY	ITCH	28:31	Mutation rewiring degron network	0.2222
p.S24F	TCGA-EE-A3J4	SKCM	TCGA	PPSY	ITCH	28:31	Mutation rewiring degron network	0.2222
p.S24F	TCGA-EE-A3J5	SKCM	TCGA	PPSY	ITCH	28:31	Mutation rewiring degron network	0.2222
p.S24F	TCGA-FS-A1ZT	SKCM	TCGA	PPSY	ITCH	28:31	Mutation rewiring degron network	0.2222
p.S24F	TCGA-GF-A6C9	SKCM	TCGA	PPSY	ITCH	28:31	Mutation rewiring degron network	0.2222
p.S24F	TCGA-GN-A266	SKCM	TCGA	PPSY	ITCH	28:31	Mutation rewiring degron network	0.2222
p.S24F	DO220895	MELA	ICGC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.2222
p.S24F	DO220912	MELA	ICGC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.2222
p.S24F	DO222635	MELA	ICGC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.2222
p.S24F	DO222653	MELA	ICGC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.2222
p.S24F	DO222749	MELA	ICGC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.2222
p.S24F	DO218849	SKCA	ICGC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.2222
p.S24F	DO37468	SKCM	ICGC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.2222
p.S24F	DO37432	SKCM	ICGC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.2222
p.S24F	DO37430	SKCM	ICGC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.2222
p.S24F	DO37444	SKCM	ICGC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.2222
p.S24F	DO37443	SKCM	ICGC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.2222
p.S24F	DO50284	SKCM	ICGC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.2222
p.S24F	DO47331	SKCM	ICGC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.2222
p.S24F	DO48604	SKCM	ICGC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.2222
p.S24F	DO51254	SKCM	ICGC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.2222
p.S24F	SIDM00080	Melanoma	GDSC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.2222
p.S24F	ACH-000730	Skin Cancer	CCLE	PPSY	ITCH	28:31	Mutation rewiring degron network	0.2222
p.S24F	ACH-002396	Bone Cancer	CCLE	PPSY	ITCH	28:31	Mutation rewiring degron network	0.2222
p.S24F	SK-MEL-5	skin	COSMIC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.2222
p.S24F	Sarc9371	bone	COSMIC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.2222
p.P26L	TCGA-D6-6516	HNSC	TCGA	PPSY	ITCH	28:31	Mutation rewiring degron network	0.2778
p.P26L	DO15623	HNSC	ICGC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.2778
p.P26S	TCGA-EE-A2A2	SKCM	TCGA	PPSY	ITCH	28:31	Mutation rewiring degron network	0.2778
p.P26S	DO37583	SKCM	ICGC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.2778
p.L18M	TCGA-EO-A3B0	UCEC	TCGA	PPSY	ITCH	28:31	Mutation rewiring degron network	0.0556
p.L18M	DO222645	ESCA	ICGC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.0556
p.L18M	DO219773	UCEC	ICGC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.0556
p.P28Q	TCGA-ET-A39R	THCA	TCGA	PPSY	ITCH	28:31	Mutation altering degron motif	0.7035
p.P28Q	DO39552	THCA	ICGC	PPSY	ITCH	28:31	Mutation altering degron motif	0.7035
p.C22S	TCGA-FP-A4BE	STAD	TCGA	PPSY	ITCH	28:31	Mutation rewiring degron network	0.1667
p.C22S	DO48016	STAD	ICGC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.1667
p.S19F	TCGA-G2-A2EO	BLCA	TCGA	PPSY	ITCH	28:31	Mutation rewiring degron network	0.0833
p.S19F	DO456	BLCA	ICGC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.0833
p.F34I	TCGA-YG-AA3N	SKCM	TCGA	PPSY	ITCH	28:31	Mutation rewiring degron network	0.25
p.F34I	DO51298	SKCM	ICGC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.25
p.S30C	SIDM00716	Squamous Cell Lung Carcinoma	GDSC	PPSY	ITCH	28:31	Mutation altering degron motif	0.643
p.S30C	ACH-000481	Lung Cancer	CCLE	PPSY	ITCH	28:31	Mutation altering degron motif	0.643
p.S30C	NCI-H2170	lung	COSMIC	PPSY	ITCH	28:31	Mutation altering degron motif	0.643
p.S19C	SIDM00235	Kidney Carcinoma	GDSC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.0833
p.S19C	SIDM00579	Neuroblastoma	GDSC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.0833
p.S19C	NB(TU)1-10	autonomic ganglia	COSMIC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.0833
p.S19C	RCC10RGB	kidney	COSMIC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.0833
p.Q39R	ACH-000387	Leukemia	CCLE	PPSY	ITCH	28:31	Mutation rewiring degron network	0.1111
p.F34C	ACH-001096	Sarcoma	CCLE	PPSY	ITCH	28:31	Mutation rewiring degron network	0.25
p.V37I	LP-1	haematopoietic and lymphoid tissue	COSMIC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.1667
p.S33R	ATN-1	haematopoietic and lymphoid tissue	COSMIC	PPSY	ITCH	28:31	Mutation rewiring degron network	0.2778
p.G20C	SW1271	lung	COSMIC	PPSY	ITCH	28:31	Mutation blocking phosphorylation signal	0.5556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KNSTRN

UniProt ID: Q9Y448

Entrez ID: 90417

Protein name: Small kinetochore-associated protein (SKAP) (Kinetochore-localized astrin-binding protein) (Kinastrin) (Kinetochore-localized astrin/SPAG5-binding protein) (TRAF4-associated factor 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KNSTRN in