DegronMD - Q9Y4B5(MTCL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G1413R	SIDM01175	Other Sarcomas	GDSC	VTPPLS	DEG_SCF_FBW7_1	1416:1421	Mutation substituting flanking lysine	0.3611
p.G1413R	SW684	soft tissue	COSMIC	VTPPLS	DEG_SCF_FBW7_1	1416:1421	Mutation substituting flanking lysine	0.3611
p.Q63R	SIDM00789	Colorectal Carcinoma	GDSC	ARPFLKDLH	DEG_APCC_DBOX_1	45:53	Mutation rewiring degron network	0.0556
p.Q63R	HCT-15	large intestine	COSMIC	ARPFLKDLH	DEG_APCC_DBOX_1	45:53	Mutation rewiring degron network	0.0556
p.A48T	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	ARPFLKDLH	DEG_APCC_DBOX_1	45:53	Mutation altering degron motif	0.7139
p.A48T	HARA	lung	COSMIC	ARPFLKDLH	DEG_APCC_DBOX_1	45:53	Mutation altering degron motif	0.7139
p.S1427A	SIDM00290	Gastric Carcinoma	GDSC	VTPPLS	DEG_SCF_FBW7_1	1416:1421	Mutation blocking phosphorylation signal	0.6111
p.S1427A	HGC-27	stomach	COSMIC	VTPPLS	DEG_SCF_FBW7_1	1416:1421	Mutation blocking phosphorylation signal	0.6111
p.S44R	SIDM00240	Cervical Carcinoma	GDSC	ARPFLKDLH	DEG_APCC_DBOX_1	45:53	Mutation rewiring degron network	0.3056
p.S44R	OMC-1	cervix	COSMIC	ARPFLKDLH	DEG_APCC_DBOX_1	45:53	Mutation rewiring degron network	0.3056
p.R59Q	SIDM01228	Melanoma	GDSC	ARPFLKDLH	DEG_APCC_DBOX_1	45:53	Mutation rewiring degron network	0.1667
p.R59Q	SIDM00415	B-Cell Non-Hodgkin's Lymphoma	GDSC	ARPFLKDLH	DEG_APCC_DBOX_1	45:53	Mutation rewiring degron network	0.1667
p.R59Q	SIDM01611	Endometrial Carcinoma	GDSC	ARPFLKDLH	DEG_APCC_DBOX_1	45:53	Mutation rewiring degron network	0.1667
p.R59Q	SIDM01760	Rhabdomyosarcoma	GDSC	ARPFLKDLH	DEG_APCC_DBOX_1	45:53	Mutation rewiring degron network	0.1667
p.E643K	SNU-C5	large intestine	COSMIC	LRRHLQFVE	DEG_APCC_DBOX_1	634:642	Mutation rewiring degron network	0.3056
p.R1428W	HGC-27	stomach	COSMIC	VTPPLS	DEG_SCF_FBW7_1	1416:1421	Mutation rewiring degron network	0.1389
p.P1841S	HLE	liver	COSMIC	PPGY	ITCH	1840:1843	Mutation altering degron motif	0.6752
p.S1411I	IGROV-1	ovary	COSMIC	PSTSS	DEG_SPOP_SBC_1	1408:1412	Mutation altering degron motif	0.8453
p.V53G	WM-115	skin	COSMIC	ARPFLKDLH	DEG_APCC_DBOX_1	45:53	Mutation altering degron motif	0.7532
p.K1426R	U031	kidney	COSMIC	VTPPLS	DEG_SCF_FBW7_1	1416:1421	Mutation substituting flanking lysine	0.3056
p.R1424Q	IGROV-1	ovary	COSMIC	VTPPLS	DEG_SCF_FBW7_1	1416:1421	Mutation rewiring degron network	0.25
p.G632A	IM-95	stomach	COSMIC	LRRHLQFVE	DEG_APCC_DBOX_1	634:642	Mutation rewiring degron network	0.2778
p.P1832S	VMRC-LCD	lung	COSMIC	GGEGTPVK	DEG_SCF_SKP2-CKS1_1	1827:1834	Mutation altering degron motif	0.6752
p.E1847K	IGR-1	skin	COSMIC	PPGY	ITCH	1840:1843	Mutation rewiring degron network	0.2222
p.R649W	CTB-1	haematopoietic and lymphoid tissue	COSMIC	LRRHLQFVE	DEG_APCC_DBOX_1	634:642	Mutation rewiring degron network	0.1389
p.Q1835R	MFE-319	endometrium	COSMIC	GGEGTPVK	DEG_SCF_SKP2-CKS1_1	1827:1834	Mutation rewiring degron network	0.3056
p.Q1835R	MFE-319	endometrium	COSMIC	PPGY	ITCH	1840:1843	Mutation rewiring degron network	0.1944
p.R635H	NCI-H630	large intestine	COSMIC	LRRHLQFVE	DEG_APCC_DBOX_1	634:642	Mutation altering degron motif	0.8244
p.G1426D	Mewo	skin	COSMIC	VTPPLS	DEG_SCF_FBW7_1	1416:1421	Mutation substituting flanking lysine	0.3056
p.M1822V	HT-1376	urinary tract	COSMIC	GGEGTPVK	DEG_SCF_SKP2-CKS1_1	1827:1834	Mutation rewiring degron network	0.1944
p.T632A	CAL-148	breast	COSMIC	LRRHLQFVE	DEG_APCC_DBOX_1	634:642	Mutation rewiring degron network	0.2778
p.R640Q	JHH-4	liver	COSMIC	LRRHLQFVE	DEG_APCC_DBOX_1	634:642	Mutation altering degron motif	0.7329
p.R1428Q	TK	haematopoietic and lymphoid tissue	COSMIC	VTPPLS	DEG_SCF_FBW7_1	1416:1421	Mutation rewiring degron network	0.1389
p.D1417G	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	VTPPLS	DEG_SCF_FBW7_1	1416:1421	Mutation altering degron motif	0.7198
p.R48W	22RV1	prostate	COSMIC	ARPFLKDLH	DEG_APCC_DBOX_1	45:53	Mutation altering degron motif	0.8634

Kaplan plot for MTCL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MTCL1

UniProt ID: Q9Y4B5

Entrez ID: 23255

Protein name: Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MTCL1 in