DegronMD - Q9Y4B5(MTCL1)

FUNCTION: Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation. Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells. {ECO:0000269|PubMed:23902687}.

GO - Biological processes (BP): establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; microtubule bundle formation [GO:0001578]; positive regulation of protein targeting to membrane [GO:0090314]; regulation of autophagy [GO:0010506]

GO - Molecular function (MF): microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]

GO - Cellular component (CC): apical plasma membrane [GO:0016324]; apicolateral plasma membrane [GO:0016327]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular space [GO:0005615]; lateral plasma membrane [GO:0016328]; microtubule bundle [GO:0097427]; midbody [GO:0030496]; spindle pole [GO:0000922]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R48W	22RV1	prostate	COSMIC	ARPFLKDLH	DEG_APCC_DBOX_1	45:53	Mutation altering degron motif	0.8634
p.S1411I	IGROV-1	ovary	COSMIC	PSTSS	DEG_SPOP_SBC_1	1408:1412	Mutation altering degron motif	0.8453
p.R635H	NCI-H630	large intestine	COSMIC	LRRHLQFVE	DEG_APCC_DBOX_1	634:642	Mutation altering degron motif	0.8244
p.V53G	WM-115	skin	COSMIC	ARPFLKDLH	DEG_APCC_DBOX_1	45:53	Mutation altering degron motif	0.7532
p.R640Q	JHH-4	liver	COSMIC	LRRHLQFVE	DEG_APCC_DBOX_1	634:642	Mutation altering degron motif	0.7329
p.D1417G	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	VTPPLS	DEG_SCF_FBW7_1	1416:1421	Mutation altering degron motif	0.7198
p.A48T	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	ARPFLKDLH	DEG_APCC_DBOX_1	45:53	Mutation altering degron motif	0.7139
p.A48T	HARA	lung	COSMIC	ARPFLKDLH	DEG_APCC_DBOX_1	45:53	Mutation altering degron motif	0.7139
p.P1841S	HLE	liver	COSMIC	PPGY	ITCH	1840:1843	Mutation altering degron motif	0.6752
p.P1832S	VMRC-LCD	lung	COSMIC	GGEGTPVK	DEG_SCF_SKP2-CKS1_1	1827:1834	Mutation altering degron motif	0.6752
p.S1427A	SIDM00290	Gastric Carcinoma	GDSC	VTPPLS	DEG_SCF_FBW7_1	1416:1421	Mutation blocking phosphorylation signal	0.6111
p.S1427A	HGC-27	stomach	COSMIC	VTPPLS	DEG_SCF_FBW7_1	1416:1421	Mutation blocking phosphorylation signal	0.6111
p.G1413R	SIDM01175	Other Sarcomas	GDSC	VTPPLS	DEG_SCF_FBW7_1	1416:1421	Mutation substituting flanking lysine	0.3611
p.G1413R	SW684	soft tissue	COSMIC	VTPPLS	DEG_SCF_FBW7_1	1416:1421	Mutation substituting flanking lysine	0.3611
p.S44R	SIDM00240	Cervical Carcinoma	GDSC	ARPFLKDLH	DEG_APCC_DBOX_1	45:53	Mutation rewiring degron network	0.3056
p.S44R	OMC-1	cervix	COSMIC	ARPFLKDLH	DEG_APCC_DBOX_1	45:53	Mutation rewiring degron network	0.3056
p.E643K	SNU-C5	large intestine	COSMIC	LRRHLQFVE	DEG_APCC_DBOX_1	634:642	Mutation rewiring degron network	0.3056
p.K1426R	U031	kidney	COSMIC	VTPPLS	DEG_SCF_FBW7_1	1416:1421	Mutation substituting flanking lysine	0.3056
p.Q1835R	MFE-319	endometrium	COSMIC	GGEGTPVK	DEG_SCF_SKP2-CKS1_1	1827:1834	Mutation rewiring degron network	0.3056
p.G1426D	Mewo	skin	COSMIC	VTPPLS	DEG_SCF_FBW7_1	1416:1421	Mutation substituting flanking lysine	0.3056

Showing 1 to 20 of 35 entries

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MTCL1

UniProt ID: Q9Y4B5

Entrez ID: 23255

Protein name: Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MTCL1 in