DegronMD - Q9Y4G6(TLN2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A1150T	TCGA-66-2769	LUSC	TCGA	AASTT	DEG_SPOP_SBC_1	1141:1145	Mutation rewiring degron network	0.1944
p.A1150T	DO26522	LUSC	ICGC	AASTT	DEG_SPOP_SBC_1	1141:1145	Mutation rewiring degron network	0.1944
p.A1148V	TCGA-AX-A1C9	UCEC	TCGA	AASTT	DEG_SPOP_SBC_1	1141:1145	Mutation rewiring degron network	0.25
p.A1148V	DO43098	UCEC	ICGC	AASTT	DEG_SPOP_SBC_1	1141:1145	Mutation rewiring degron network	0.25
p.A1141S	TCGA-DX-A6YV	SARC	TCGA	AASTT	DEG_SPOP_SBC_1	1141:1145	Mutation altering degron motif	0.7588
p.A1141S	DO220011	SARC	ICGC	AASTT	DEG_SPOP_SBC_1	1141:1145	Mutation altering degron motif	0.7588
p.R1138H	TCGA-YZ-A985	UVM	TCGA	AASTT	DEG_SPOP_SBC_1	1141:1145	Mutation rewiring degron network	0.25
p.A1152S	DO229027	LICA	ICGC	AASTT	DEG_SPOP_SBC_1	1141:1145	Mutation rewiring degron network	0.1389
p.A1150S	DO229032	LICA	ICGC	AASTT	DEG_SPOP_SBC_1	1141:1145	Mutation rewiring degron network	0.1944
p.A1148S	DO231075	LUSC	ICGC	AASTT	DEG_SPOP_SBC_1	1141:1145	Mutation rewiring degron network	0.25
p.A1148S	SIDM00602	Gastric Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	1141:1145	Mutation rewiring degron network	0.25
p.A1148S	SIDM00355	Non-Small Cell Lung Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	1141:1145	Mutation rewiring degron network	0.25
p.A1148S	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	1141:1145	Mutation rewiring degron network	0.25
p.A1148S	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	1141:1145	Mutation rewiring degron network	0.25
p.A1148S	SIDM00618	Hepatocellular Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	1141:1145	Mutation rewiring degron network	0.25
p.A1148S	SIDM00302	Other Solid Cancers	GDSC	AASTT	DEG_SPOP_SBC_1	1141:1145	Mutation rewiring degron network	0.25
p.A1148S	SIDM01658	Unknown	GDSC	AASTT	DEG_SPOP_SBC_1	1141:1145	Mutation rewiring degron network	0.25
p.A1148S	SIDM01618	B-Lymphoblastic Leukemia	GDSC	AASTT	DEG_SPOP_SBC_1	1141:1145	Mutation rewiring degron network	0.25
p.A1148T	SIDM01681	Non-Cancerous	GDSC	AASTT	DEG_SPOP_SBC_1	1141:1145	Mutation rewiring degron network	0.25
p.D1146G	ACH-001413	Bladder Cancer	CCLE	AASTT	DEG_SPOP_SBC_1	1141:1145	Mutation rewiring degron network	0.3056
p.D1146G	LNCaP-Clone-FGC	prostate	COSMIC	AASTT	DEG_SPOP_SBC_1	1141:1145	Mutation rewiring degron network	0.3056

Kaplan plot for TLN2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TLN2

UniProt ID: Q9Y4G6

Entrez ID: 83660

Protein name: Talin-2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TLN2 in