DegronMD - Q9Y4W2(LAS1L)

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GO - Molecular function (MF): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K551N	TCGA-21-5784	LUSC	TCGA	PASSS	DEG_SPOP_SBC_1	541:545	Mutation blocking ubiquitination signal	0.6111
p.K551N	DO27271	LUSC	ICGC	PASSS	DEG_SPOP_SBC_1	541:545	Mutation blocking ubiquitination signal	0.6111
p.V539I	TCGA-AP-A1DV	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.2778
p.V539I	TCGA-CM-6164	COAD	TCGA	PASSS	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.2778
p.V539I	DO7930	COAD	ICGC	PASSS	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.2778
p.V539I	DO43186	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.2778
p.A542V	TCGA-D7-6528	STAD	TCGA	PASSS	DEG_SPOP_SBC_1	541:545	Mutation altering degron motif	0.5825
p.A542V	DO38547	STAD	ICGC	PASSS	DEG_SPOP_SBC_1	541:545	Mutation altering degron motif	0.5825
p.S544C	DO222974	BTCA	ICGC	PASSS	DEG_SPOP_SBC_1	541:545	Mutation altering degron motif	0.7541
p.G547R	SIDM00958	Chronic Myelogenous Leukemia	GDSC	PASSS	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.2778
p.G547R	ACH-000920	Leukemia	CCLE	PASSS	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.2778
p.G547R	CML-T1	haematopoietic and lymphoid tissue	COSMIC	PASSS	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.2778
p.E542K	SNU-1040	large intestine	COSMIC	PASSS	DEG_SPOP_SBC_1	541:545	Mutation altering degron motif	0.7022
p.G542D	IGROV-1	ovary	COSMIC	PASSS	DEG_SPOP_SBC_1	541:545	Mutation altering degron motif	0.7198

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons