DegronMD - Q9Y4X4(KLF12)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S92F	TCGA-21-1079	LUSC	TCGA	AVSSS	DEG_SPOP_SBC_1	95:99	Mutation blocking phosphorylation signal	0.6944
p.S92F	DO26846	LUSC	ICGC	AVSSS	DEG_SPOP_SBC_1	95:99	Mutation blocking phosphorylation signal	0.6944
p.A95P	TCGA-66-2770	LUSC	TCGA	AVSSS	DEG_SPOP_SBC_1	95:99	Mutation altering degron motif	0.6392
p.A95P	DO27556	LUSC	ICGC	AVSSS	DEG_SPOP_SBC_1	95:99	Mutation altering degron motif	0.6392
p.I130T	TCGA-AA-3811	COAD	TCGA	ASSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1667
p.I130T	DO7962	COAD	ICGC	ASSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1667
p.S139L	TCGA-AP-A056	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	136:140	Mutation altering degron motif	0.7667
p.S139L	DO43971	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	136:140	Mutation altering degron motif	0.7667
p.S118L	TCGA-BF-AAP1	SKCM	TCGA	PSSTS	DEG_SPOP_SBC_1	110:114	Mutation rewiring degron network	0.2222
p.S118L	TCGA-RD-A8N9	STAD	TCGA	PSSTS	DEG_SPOP_SBC_1	110:114	Mutation rewiring degron network	0.2222
p.S118L	DO222875	MELA	ICGC	PSSTS	DEG_SPOP_SBC_1	110:114	Mutation rewiring degron network	0.2222
p.S118L	DO219464	SKCM	ICGC	PSSTS	DEG_SPOP_SBC_1	110:114	Mutation rewiring degron network	0.2222
p.S118L	DO50141	STAD	ICGC	PSSTS	DEG_SPOP_SBC_1	110:114	Mutation rewiring degron network	0.2222
p.S118L	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	110:114	Mutation rewiring degron network	0.2222
p.N87S	TCGA-BS-A0UF	UCEC	TCGA	AVSSS	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.1111
p.N87S	DO41488	UCEC	ICGC	AVSSS	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.1111
p.S102F	TCGA-DA-A1HV	SKCM	TCGA	AVSSS	DEG_SPOP_SBC_1	95:99	Mutation blocking phosphorylation signal	0.6944
p.S102F	TCGA-DA-A1HV	SKCM	TCGA	PSSTS	DEG_SPOP_SBC_1	110:114	Mutation blocking phosphorylation signal	0.5556
p.S102F	TCGA-EE-A20F	SKCM	TCGA	AVSSS	DEG_SPOP_SBC_1	95:99	Mutation blocking phosphorylation signal	0.6944
p.S102F	TCGA-EE-A20F	SKCM	TCGA	PSSTS	DEG_SPOP_SBC_1	110:114	Mutation blocking phosphorylation signal	0.5556
p.S102F	DO37659	SKCM	ICGC	AVSSS	DEG_SPOP_SBC_1	95:99	Mutation blocking phosphorylation signal	0.6944
p.S102F	DO37659	SKCM	ICGC	PSSTS	DEG_SPOP_SBC_1	110:114	Mutation blocking phosphorylation signal	0.5556
p.S102F	DO37961	SKCM	ICGC	AVSSS	DEG_SPOP_SBC_1	95:99	Mutation blocking phosphorylation signal	0.6944
p.S102F	DO37961	SKCM	ICGC	PSSTS	DEG_SPOP_SBC_1	110:114	Mutation blocking phosphorylation signal	0.5556
p.T131P	TCGA-DU-6392	LGG	TCGA	ASSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1944
p.T131P	DO22237	LGG	ICGC	ASSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1944
p.A95V	TCGA-EE-A2GC	SKCM	TCGA	AVSSS	DEG_SPOP_SBC_1	95:99	Mutation altering degron motif	0.5825
p.A95V	DO37839	SKCM	ICGC	AVSSS	DEG_SPOP_SBC_1	95:99	Mutation altering degron motif	0.5825
p.S97L	TCGA-JY-A93C	ESCA	TCGA	AVSSS	DEG_SPOP_SBC_1	95:99	Mutation altering degron motif	0.7667
p.A136T	TCGA-NC-A5HI	LUSC	TCGA	ASSSS	DEG_SPOP_SBC_1	136:140	Mutation altering degron motif	0.7139
p.A136T	DO45461	LUSC	ICGC	ASSSS	DEG_SPOP_SBC_1	136:140	Mutation altering degron motif	0.7139
p.L123V	DO48414	BLCA	ICGC	PSSTS	DEG_SPOP_SBC_1	110:114	Mutation rewiring degron network	0.0833
p.R122H	DO230343	COCA	ICGC	PSSTS	DEG_SPOP_SBC_1	110:114	Mutation rewiring degron network	0.1111
p.R122H	SIDM00429	B-Lymphoblastic Leukemia	GDSC	PSSTS	DEG_SPOP_SBC_1	110:114	Mutation rewiring degron network	0.1111
p.R122H	SIDM01569	Hepatocellular Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	110:114	Mutation rewiring degron network	0.1111
p.R122C	DO233920	GACA	ICGC	PSSTS	DEG_SPOP_SBC_1	110:114	Mutation rewiring degron network	0.1111
p.R122S	DO229024	LICA	ICGC	PSSTS	DEG_SPOP_SBC_1	110:114	Mutation rewiring degron network	0.1111
p.T104K	DO229037	LICA	ICGC	AVSSS	DEG_SPOP_SBC_1	95:99	Mutation blocking phosphorylation signal	0.6389
p.T104K	DO229037	LICA	ICGC	PSSTS	DEG_SPOP_SBC_1	110:114	Mutation blocking phosphorylation signal	0.6111
p.P110H	DO229008	LICA	ICGC	PSSTS	DEG_SPOP_SBC_1	110:114	Mutation altering degron motif	0.7694
p.S119C	SIDM00344	Non-Small Cell Lung Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	110:114	Mutation blocking phosphorylation signal	0.6389
p.S119C	ACH-000596	Lung Cancer	CCLE	PSSTS	DEG_SPOP_SBC_1	110:114	Mutation blocking phosphorylation signal	0.6389
p.S119C	LCLC-97TM1	lung	COSMIC	PSSTS	DEG_SPOP_SBC_1	110:114	Mutation blocking phosphorylation signal	0.6389
p.V142I	SIDM00930	Osteosarcoma	GDSC	ASSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.2778
p.V142I	CAL-72	bone	COSMIC	ASSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.2778
p.S140L	SIDM00783	Colorectal Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	136:140	Mutation altering degron motif	0.7667
p.S140L	ACH-000971	Colon/Colorectal Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	136:140	Mutation altering degron motif	0.7667
p.S140L	HCT-116	large intestine	COSMIC	ASSSS	DEG_SPOP_SBC_1	136:140	Mutation altering degron motif	0.7667

Kaplan plot for KLF12 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KLF12

UniProt ID: Q9Y4X4

Entrez ID: 11278

Protein name: Krueppel-like factor 12 (Transcriptional repressor AP-2rep)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KLF12 in