DegronMD - Q9Y5N1(HRH3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G294S	TCGA-CV-7245	HNSC	TCGA	PTSSS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.0833
p.G294S	DO14322	HNSC	ICGC	PTSSS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.0833
p.P317L	TCGA-DD-A4NH	LIHC	TCGA	PTSSS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.0556
p.P317L	DO44907	LIHC	ICGC	PTSSS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.0556
p.P317S	TCGA-KN-8428	KICH	TCGA	PTSSS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.0556
p.P317S	DO220484	KICH	ICGC	PTSSS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.0556
p.G298S	DO233109	GACA	ICGC	PTSSS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.1944
p.P303L	DO220899	MELA	ICGC	PTSSS	DEG_SPOP_SBC_1	303:307	Mutation altering degron motif	0.7582
p.A301T	SIDM02050	Colorectal Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.2778
p.T304N	ACH-000128	Brain Cancer	CCLE	PTSSS	DEG_SPOP_SBC_1	303:307	Mutation altering degron motif	0.5944
p.V300M	ACH-000729	Lung Cancer	CCLE	PTSSS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.25
p.G297S	ACH-000822	Skin Cancer	CCLE	PTSSS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.1667
p.E315K	Mewo	skin	COSMIC	PTSSS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.1111
p.E315K	KYSE-520	oesophagus	COSMIC	PTSSS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.1111

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons