DegronMD - Q9Y613(FHOD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E435K	TCGA-32-2616	GBM	TCGA	ADTSS	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.3056
p.E435K	DO13462	GBM	ICGC	ADTSS	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.3056
p.A386T	TCGA-AA-3713	COAD	TCGA	PTSST	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.1944
p.A386T	DO8400	COAD	ICGC	PTSST	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.1944
p.I424V	TCGA-AA-A01R	COAD	TCGA	ADTSS	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.1667
p.I424V	DO7934	COAD	ICGC	ADTSS	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.1667
p.A398T	TCGA-AC-A62V	BRCA	TCGA	PTSST	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.25
p.A398T	DO50024	BRCA	ICGC	PTSST	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.25
p.A404T	TCGA-BG-A221	UCEC	TCGA	PTSST	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.0833
p.A404T	DO42384	UCEC	ICGC	PTSST	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.0833
p.R436M	TCGA-BQ-7049	KIRP	TCGA	ADTSS	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.2778
p.R436M	DO20853	KIRP	ICGC	ADTSS	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.2778
p.G396S	TCGA-BS-A0UF	UCEC	TCGA	PTSST	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.3056
p.G396S	DO41488	UCEC	ICGC	PTSST	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.3056
p.S1087F	TCGA-YC-A89H	BLCA	TCGA	VQSSS	DEG_SPOP_SBC_1	1074:1078	Mutation rewiring degron network	0.0833
p.S1087F	DO51948	BLCA	ICGC	VQSSS	DEG_SPOP_SBC_1	1074:1078	Mutation rewiring degron network	0.0833
p.S1087F	SIDM00153	T-Lymphoblastic Leukemia	GDSC	VQSSS	DEG_SPOP_SBC_1	1074:1078	Mutation rewiring degron network	0.0833
p.S1087F	ACH-000964	Leukemia	CCLE	VQSSS	DEG_SPOP_SBC_1	1074:1078	Mutation rewiring degron network	0.0833
p.L400M	DO229018	LICA	ICGC	PTSST	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.1944
p.P397T	DO229019	LICA	ICGC	PTSST	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.2778
p.A404D	DO229025	LICA	ICGC	PTSST	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.0833
p.P403T	DO229052	LICA	ICGC	PTSST	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.1111
p.S434R	DO27875	ORCA	ICGC	ADTSS	DEG_SPOP_SBC_1	430:434	Mutation altering degron motif	0.7427
p.V389A	DO229242	THCA	ICGC	PTSST	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.2778
p.K440R	SIDM00074	Burkitt's Lymphoma	GDSC	ADTSS	DEG_SPOP_SBC_1	430:434	Mutation substituting flanking lysine	0.2778
p.K440R	BL-70	haematopoietic and lymphoid tissue	COSMIC	ADTSS	DEG_SPOP_SBC_1	430:434	Mutation substituting flanking lysine	0.2778
p.A441T	SIDM01197	Colorectal Carcinoma	GDSC	ADTSS	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.1389
p.A441T	SNU-C1	large intestine	COSMIC	ADTSS	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.1389
p.R442Q	SIDM00687	Gastric Carcinoma	GDSC	ADTSS	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.1111
p.R442Q	ACH-000793	Gastric Cancer	CCLE	ADTSS	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.1111
p.R442Q	KATOIII	stomach	COSMIC	ADTSS	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.1111
p.I438T	SIDM01188	Pancreatic Carcinoma	GDSC	ADTSS	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.2222
p.I438T	ACH-000114	Pancreatic Cancer	CCLE	ADTSS	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.2222
p.I438T	SU8686	pancreas	COSMIC	ADTSS	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.2222
p.G402S	SIDM00882	Breast Carcinoma	GDSC	PTSST	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.1389
p.G402S	HCC1419	breast	COSMIC	PTSST	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.1389
p.P1086L	SIDM00153	T-Lymphoblastic Leukemia	GDSC	VQSSS	DEG_SPOP_SBC_1	1074:1078	Mutation rewiring degron network	0.1111
p.P1086L	ACH-000964	Leukemia	CCLE	VQSSS	DEG_SPOP_SBC_1	1074:1078	Mutation rewiring degron network	0.1111
p.S393P	ACH-000305	Esophageal Cancer	CCLE	PTSST	DEG_SPOP_SBC_1	391:395	Mutation altering degron motif	0.6752
p.S393F	ACH-000793	Gastric Cancer	CCLE	PTSST	DEG_SPOP_SBC_1	391:395	Mutation altering degron motif	0.7982
p.S433F	ACH-001484	Leukemia	CCLE	ADTSS	DEG_SPOP_SBC_1	430:434	Mutation altering degron motif	0.7982
p.S433F	ACH-001485	Leukemia	CCLE	ADTSS	DEG_SPOP_SBC_1	430:434	Mutation altering degron motif	0.7982

Kaplan plot for FHOD1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FHOD1

UniProt ID: Q9Y613

Entrez ID: 29109

Protein name: FH1/FH2 domain-containing protein 1 (Formin homolog overexpressed in spleen 1) (FHOS) (Formin homology 2 domain-containing protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FHOD1 in