DegronMD - Q9Y6X2(PIAS3)

PIAS3

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E156D	TCGA-06-5416	GBM	TCGA	ASTSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.2222
p.H159R	TCGA-2Y-A9H4	LIHC	TCGA	ASTSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.1389
p.I142M	TCGA-66-2785	LUSC	TCGA	ASTSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.1667
p.R143W	TCGA-AA-3864	COAD	TCGA	ASTSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.1944
p.S431I	TCGA-AP-A0LM	UCEC	TCGA	PPGY	ITCH	420:423	Mutation blocking phosphorylation signal	0.5556
p.S431I	DO43306	UCEC	ICGC	PPGY	ITCH	420:423	Mutation blocking phosphorylation signal	0.5556
p.R143Q	TCGA-BR-8363	STAD	TCGA	ASTSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.1944
p.P420L	TCGA-D1-A17U	UCEC	TCGA	PPGY	ITCH	420:423	Mutation altering degron motif	0.7582
p.P420L	DO41887	UCEC	ICGC	PPGY	ITCH	420:423	Mutation altering degron motif	0.7582
p.T146A	TCGA-EO-A3AY	UCEC	TCGA	ASTSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.2778
p.A147V	DO20855	KIRP	ICGC	ASTSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.3056
p.L426V	DO23428	LINC	ICGC	PPGY	ITCH	420:423	Mutation rewiring degron network	0.25
p.Q154L	DO23690	LUAD	ICGC	ASTSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.2778
p.R154Q	SIDM00602	Gastric Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.2778
p.R154Q	ACH-000919	Gastric Cancer	CCLE	ASTSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.2778
p.R154Q	IM-95	stomach	COSMIC	ASTSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc