DegronMD: protein-targeted degradation, mutation and drug response to degrons

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BSML CPH CGC

Q04912

(DYR)

Drug: Foretinib

Cancer code: ALL

Cancer type: lymphoblastic_leukemia

Drug treatment table

Degron	Position	Sample	Mutation	IC50(uM)
DYR	292..294	SIDM00145	p.D1063N	0.46
DYR	292..294	SIDM00145	p.D1063N	0.4244
DYR	292..294	SIDM00145	p.A285T	0.46
DYR	292..294	SIDM00145	p.A285T	0.4244
DYR	292..294	SIDM00121	p.G357S	0.2992
DYR	292..294	SIDM00121	p.G357S	0.2245
DYR	292..294	SIDM01007	p.Q1377H	0.1908
DYR	292..294	SIDM01007	p.Q1377H	0.4275
DYR	292..294	SIDM01007	p.Q563*	0.1908
DYR	292..294	SIDM01007	p.Q563*	0.4275
DYR	292..294	SIDM01007	p.A324T	0.1908
DYR	292..294	SIDM01007	p.A324T	0.4275
DYR	1016..1018	SIDM00145	p.D1063N	0.46
DYR	1016..1018	SIDM00145	p.D1063N	0.4244
DYR	1016..1018	SIDM00145	p.A285T	0.46
DYR	1016..1018	SIDM00145	p.A285T	0.4244
DYR	1016..1018	SIDM00121	p.G357S	0.2992
DYR	1016..1018	SIDM00121	p.G357S	0.2245
DYR	1016..1018	SIDM01007	p.Q1377H	0.1908
DYR	1016..1018	SIDM01007	p.Q1377H	0.4275
DYR	1016..1018	SIDM01007	p.Q563*	0.1908
DYR	1016..1018	SIDM01007	p.Q563*	0.4275
DYR	1016..1018	SIDM01007	p.A324T	0.1908
DYR	1016..1018	SIDM01007	p.A324T	0.4275

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