Gene: Tmem19

Basic information

Tag Content
Uniprot ID A0A1W2P7P6
Entrez ID
Genbank protein ID
Genbank nucleotide ID
Ensembl protein ID ENSMUSP00000152044; ENSMUSP00000151753;
Ensembl nucleotide ID ENSMUSG00000069520
Gene name Transmembrane protein 19
Gene symbol Tmem19
Organism Mus musculus
NCBI taxa ID 10090
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MSMTASTYYG NFRPVSPWRW LFSVVVPVVI ACNGFKKKSL DHSGALGGLV VGFILTIANF 60
SFFTSLMTFF LSSSKLTKWR GNIKKQLDSE YKEGGQRNWV QVFCNGAVPT ELALLYMIEN 120
GPGEMPIDFS KQHTASWMCL SLLAALASSA GDTWASEVAP VLSKSSPRLI TTWEKVPVGT 180
NGGVTAVGLA SSLLGGTFVG LAYFLTQLVF VNDLDISAPQ WPIIAFGGVA GLFGSLVDSF 240
LGATMQFSGL DERTGLVVSS PTQETKHIAG KPILDNNAVN LFSSVLVALL LPTAASGFWP 300
RE 302

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

  

Gene expression in different tissues (ENCODE)

  

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologTMEM19538974A7E3R1Bos taurusPredictionMore>>
1:1 orthologTMEM19A0A452FPZ7Capra hircusPredictionMore>>
1:1 orthologTMEM1955266Q96HH6Homo sapiensPublicationMore>>
1:1 orthologTmem19A0A1W2P7P6Mus musculusPredictionMore>>
1:1 orthologTMEM19452078A0A2I3SMV0Pan troglodytesPredictionMore>>
1:1 orthologTMEM19100343889G1T3J4Oryctolagus cuniculusPredictionMore>>
1:1 orthologA0A0G2L6U7Danio rerioPredictionMore>>

Identified variants/mutations related to cleft phenotype

Gene symbol Significant Variants/SNPS Methods PubMed ID
TMEM19rs2304269A>GGWAS28232668
TMEM19rs7967428A>GGWAS28232668

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence

GO:Biological Process

GO ID GO Term Evidence

GO:Cellular Component

GO ID GO Term Evidence

Reactome Pathway

Reactome ID Reactome Term Evidence

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0472 Membrane
KW-1267 Proteomics identification
KW-1185 Reference proteome
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR002794 DUF92_TMEM19

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF01940 DUF92

Protein-miRNA interaction