Gene: Cplane2

Basic information

Tag Content
Uniprot ID A2A825
Entrez ID 76166
Genbank protein ID
Genbank nucleotide ID NM_001081174.2
Ensembl protein ID ENSMUSP00000095422
Ensembl nucleotide ID ENSMUSG00000073733
Gene name Ciliogenesis and planar polarity effector 2
Gene symbol Cplane2
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CLO
Developmental stage
Data sources Manually collected
Reference 25807483
Functional description Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells (By similarity).
Sequence
MARPPMHGSV IVPDWHETVE GKEYLACILR KNRRREFGLL ERPVLPPSVV IDTASYKIFV 60
SGKSGVGKTA LVAKLAGLEV PIVHHETTGI QTTVVFWPAK LKASDCVVMF RFEFWDCGES 120
ALKKFDHMLP ACKENADAFL FLFSFTDRAS FEDLPGQLTR VAGEAPGLVK IVIGSKFDQY 180
MHTDVPARDL TAFRQAWELP LFRVKSVPGR RLADGRTLDG RAGLADTAHV LNGLAEQLWH 240
QDQVAAGLLP SSPESAPG 258

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologCPLANE2516664A0A3Q1LNI2Bos taurusPredictionMore>>
1:1 orthologCPLANE2106503627A0A452DRN3Capra hircusPredictionMore>>
1:1 orthologCPLANE279363Q9BU20Homo sapiensPredictionMore>>
1:1 orthologCplane276166A2A825CLOMus musculusPublicationMore>>
1:1 orthologCPLANE2741051H2PY49Pan troglodytesPredictionMore>>
1:1 orthologCPLANE2F1SUS6Sus scrofaPredictionMore>>
1:1 orthologCplane2A0A0G2K9E9Rattus norvegicusPredictionMore>>
1:1 orthologcplane2F1RBX6Danio rerioPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0003924 GTPase activityIEA
GO:0005525 GTP bindingIEA

GO:Biological Process

GO ID GO Term Evidence
GO:0006887 exocytosisIEA
GO:0015031 protein transportIEA
GO:0017157 regulation of exocytosisISS
GO:0031338 regulation of vesicle fusionISS
GO:0034613 cellular protein localizationISS
GO:0060271 cilium assemblyISS

GO:Cellular Component

GO ID GO Term Evidence
GO:0005654 nucleoplasmISO
GO:0005737 cytoplasmIEA
GO:0036064 ciliary basal bodyISS

Reactome Pathway

Reactome ID Reactome Term Evidence

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0966 Cell projection
KW-0969 Cilium
KW-0970 Cilium biogenesis/degradation
KW-0963 Cytoplasm
KW-0206 Cytoskeleton
KW-0268 Exocytosis
KW-0342 GTP-binding
KW-0547 Nucleotide-binding
KW-0653 Protein transport
KW-1185 Reference proteome
KW-0813 Transport

Interpro

InterPro ID InterPro Term
IPR027417 P-loop_NTPase
IPR039677 RSG1
IPR001806 Small_GTPase

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF00071 Ras