| Tag | Content |
|---|---|
| Uniprot ID | D3YWE6 |
| Entrez ID | 433938 |
| Genbank protein ID | |
| Genbank nucleotide ID | NM_001081235.1 |
| Ensembl protein ID | ENSMUSP00000092034 |
| Ensembl nucleotide ID | ENSMUSG00000070576 |
| Gene name | Transcriptional activator MN1 |
| Gene symbol | Mn1 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | E14.5 |
| Data sources | Manually collected |
| Reference | 15870292 |
| Functional description | Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate (PubMed:18948418). Required during later stages of palate development for normal growth and medial fusion of the palatal shelves (PubMed:18948418). Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL (PubMed:19386590). Necessary for normal development of the membranous bones of the skull (PubMed:15870292). May play a role in tumor suppression (By similarity). |
| Sequence | MFGLDQFEPQ INSRHAGQGE GNFNEAGLSM NAHFKAPAFH AGPPTGPVDP AISALGEPPI 60 LGLNMEPYGF HARSHSELHA GGLQAQPVHG FFGGQQPHHS HPGGHHPHQH HPHFGGNFGG 120 PDPGASCLHG GRLLGYGGAA GGLGSQPPFA ESYEHMAESQ GPEGFGPQRP GNLPDFHSSG 180 TSGHAVPAPC LPLDQSPNRA ASFHGLSASS GSDSHSLEPR RVTNQGAVDS LEYNYPSEPP 240 SGHFDMFSPS DSEGQLPHYA AGRQVPGGAF PGASAMPRAS GMVGLSKMHS QPPQPPPQQQ 300 QPQHGVFFER FGGARKMPVG LEPAVGSRHP LMQPPQQAPP PPQQPPPQQQ PPPPGLLVRQ 360 NSCPPALPRP QQGEAGTPSG GLQDGGPMLP SQHAQFEYPI HRLENRSMHP YSEPVFSMQH 420 PPPQQAPNQR LQHFDAPPYM NVAKRPRFDF PGSAGVDRCA SWNGSMHNGT LDNQLSPSAY 480 PGLPGEFTPP VPDSFSSGPP LQHPGPDHQS LQQQQQQQQQ QQQQQQQQQQ QQQQQQQRQN 540 AALMIKQMAS RNQQQRLRQP NLAQLGHPGD VGQGGLVHGG SVGGLAQTNF EREGGSAGAG 600 RLSGFEQQAP HLAQESAWFP GPHPPGDLLP RRMGGAGLPT DCGPHDPALA PPPAPGGSGV 660 LFRGSLQEPL RMPGEGHVPA LASPGLQFGG SLAGLGQLQS PGAGVGLPNA PSERRPPPPD 720 FPAPALGGQP GFPFGSGSRQ ATPHSAPGVN SPPSAGSGSS GAGGGAYPPQ PDFQPSQRNS 780 ASKLGALSLG SFNKPSSKDN LFGQSCLAAL STACQNMIAS LGAPNLNVTF NKKNPPEGKR 840 KLSQNEPDSA VAAGNPGSDY FPGGTTPGAP GPGGPSGTSG GGSKASGPPN PPIQGDSTSL 900 SPNYTLESTS GNDGKPVPGG SGRGRGRRKR DSGHVSPGTF FDKYSTAPDS GGAPGVSPGQ 960 QQAPGSAAGG SSVNEARGPT PHEKALTSPS WGKGAELLLG DQPDLMASLD STAKSDGSSP 1020 HVGEFASDEV STSYANEDEV SSSSDNTTAL AKASRSPLVT SSPKLPPRGV GAGEHTPKAS 1080 ALGLGILSTS TSTPDSYGGG VGTGHPGTPG LEQVRTPTSS SGAQPPDEIH PLEILQAQIQ 1140 LQRQQFSISE DQPLGLKGSK KAECAVGASG AQNGDSELGS CCSEAVKSAM STIDLDSLMA 1200 EHSTTWYMPP DKALVDGGDE DKTLAPWEKA KSQNPNNKEA HDHPTNKASA TQPGSHLQCL 1260 TVHCTDGDPK ARTSVPTWRS LHSDISNRFG TFVAALT 1297 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MN1 | 102187517 | A0A452FGG2 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | MN1 | 4330 | Q10571 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Mn1 | 433938 | D3YWE6 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | MN1 | 458730 | A0A2I3SC32 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Mn1 | 498194 | D4AAP6 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | mn1b | 572077 | B8JKI7 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001957 | intramembranous ossification | IMP |
| GO:0006355 | regulation of transcription, DNA-templated | IEA |
| GO:0007275 | multicellular organism development | IEA |
| GO ID | GO Term | Evidence |
|---|
| Reactome ID | Reactome Term | Evidence |
|---|
| InterPro ID | InterPro Term |
|---|---|
| IPR037644 | MN1 |