| Tag | Content |
|---|---|
| Uniprot ID | H2QDH3; A0A2J8MFG6; |
| Entrez ID | 468413 |
| Genbank protein ID | JAA37618.1; JAA00517.1; JAA23392.1; |
| Genbank nucleotide ID | XM_523802.5 |
| Ensembl protein ID | ENSPTRP00000016018 |
| Ensembl nucleotide ID | ENSPTRG00000009430 |
| Gene name | Noggin |
| Gene symbol | NOG |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. |
| Sequence | MERCPSLGVT LYALVVVLGL RATPAGGQHY LHIRPAPSDN LPLVDLIEHP DPIFDPKEKD 60 LNETLLRSLL GGHYDPGFMA TSPPEDRPGG GGGAAGGAED LAELDQLLRQ RPSGAMPSEI 120 KGLEFSEGLA QGKKQRLSKK LRRKLQMWLW SQTFCPVLYA WNDLGSRFWP RYVKVGSCFS 180 KRSCSVPEGM VCKPSKSVHL TVLRWRCQRR GGQRCAWIPI QYPIISECKC SC 232 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | NOG | 538769 | G3N3L0 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | NOG | 102183633 | A0A2Z4FR29 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | NOG | 9241 | Q13253 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Nog | 18121 | P97466 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | NOG | 468413 | H2QDH3 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | NOG | 574073 | B8XVN4 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Nog | 25495 | G3V8X8 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005615 | extracellular space |
| GO:0019955 | cytokine binding |
| GO:0042803 | protein homodimerization activity |
| GO:0055009 | atrial cardiac muscle tissue morphogenesis |
| GO:0048318 | axial mesoderm development |
| GO:0061312 | BMP signaling pathway involved in heart development |
| GO:0051216 | cartilage development |
| GO:0021533 | cell differentiation in hindbrain |
| GO:0009953 | dorsal/ventral pattern formation |
| GO:0042733 | embryonic digit morphogenesis |
| GO:0060272 | embryonic skeletal joint morphogenesis |
| GO:0003203 | endocardial cushion morphogenesis |
| GO:0001706 | endoderm formation |
| GO:0001837 | epithelial to mesenchymal transition |
| GO:0060325 | face morphogenesis |
| GO:0060825 | fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation |
| GO:0061384 | heart trabecula morphogenesis |
| GO:0001701 | in utero embryonic development |
| GO:0060425 | lung morphogenesis |
| GO:0003149 | membranous septum morphogenesis |
| GO:0001707 | mesoderm formation |
| GO:0042474 | middle ear morphogenesis |
| GO:0008045 | motor neuron axon guidance |
| GO:2001234 | negative regulation of apoptotic signaling pathway |
| GO:0048712 | negative regulation of astrocyte differentiation |
| GO:0030514 | negative regulation of BMP signaling pathway |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| GO:0060044 | negative regulation of cardiac muscle cell proliferation |
| GO:0061037 | negative regulation of cartilage development |
| GO:0030336 | negative regulation of cell migration |
| GO:0060302 | negative regulation of cytokine activity |
| GO:1905006 | negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation |
| GO:0045668 | negative regulation of osteoblast differentiation |
| GO:0060394 | negative regulation of pathway-restricted SMAD protein phosphorylation |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0001839 | neural plate morphogenesis |
| GO:0001843 | neural tube closure |
| GO:0048570 | notochord morphogenesis |
| GO:0001649 | osteoblast differentiation |
| GO:0003151 | outflow tract morphogenesis |
| GO:0061626 | pharyngeal arch artery morphogenesis |
| GO:0021983 | pituitary gland development |
| GO:0090190 | positive regulation of branching involved in ureteric bud morphogenesis |
| GO:0050679 | positive regulation of epithelial cell proliferation |
| GO:0090193 | positive regulation of glomerulus development |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0060513 | prostatic bud formation |
| GO:2000313 | regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation |
| GO:0035019 | somatic stem cell population maintenance |
| GO:0061053 | somite development |
| GO:0021510 | spinal cord development |
| GO:0060676 | ureteric bud formation |
| GO:0003223 | ventricular compact myocardium morphogenesis |
| GO:0042060 | wound healing |