Gene: Nat1

Basic information

Tag Content
Uniprot ID P50297
Entrez ID 116631
Genbank protein ID AAA70156.1; AAA70158.1; AAA56771.1; AAH78765.1; AAA70157.1;
Genbank nucleotide ID XM_006253001.2; XM_006253002.3; NM_053853.2; NM_001037315.1; XM_006253004.3; NM_001037316.1; XM_017599978.1;
Ensembl protein ID ENSRNOP00000018854; ENSRNOP00000070053;
Ensembl nucleotide ID ENSRNOG00000014055
Gene name Arylamine N-acetyltransferase 1
Gene symbol Nat1
Organism Rattus norvegicus
NCBI taxa ID 10116
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Acetylates both arylamines and arylalkylamines.
Sequence
MDIEAYFERI GYKNSVNKLD LATLTEVLQH QMRAVPFENL SMHCGEAMCL GLEATFDHIV 60
RKKRGGWCLQ VNHLLYWALT KMGFETTMLG GYVYITPVNK YSSEMVHLLV QVTISDRNYI 120
VDSAYGSSYQ MWEPLELTSG KDQPQVPAIF RLTEENGTWY LDQIRREQDV PNQEFVNSDL 180
LEKSKYRKIY SFTLEPRTIE DFEYVNTYLQ TSPASVFVST SFCSLQTSEG VCCLIGSTLT 240
SRRFSYKDNV DLVEFKSLTE EEIEDVLKTT FGISLEKKFV PKHGELVFTI

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologNAT210P11245Homo sapiensPublicationMore>>
1:1 orthologNat1A0A1D5RLG2Mus musculusPredictionMore>>
1:1 orthologNAT2464024H2QVT5Pan troglodytesPredictionMore>>
1:1 orthologNat1116631P50297Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005829 cytosol
GO:0004060 arylamine N-acetyltransferase activity
GO:0007568 aging
GO:0001889 liver development
GO:0097068 response to thyroxine

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0007 Acetylation
KW-0012 Acyltransferase
KW-0963 Cytoplasm
KW-1185 Reference proteome
KW-0808 Transferase

Interpro

InterPro ID InterPro Term
IPR001447 Arylamine_N-AcTrfase
IPR038765 Papain-like_cys_pep_sf

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF00797 Acetyltransf_2