CleftGeneDB-Search

Gene: Rps26

Basic information

Tag	Content
Uniprot ID	P62855; P02383; P70394; Q06722;
Entrez ID	27370
Genbank protein ID	AAH81452.1; BAB25586.1; AAB07729.1; BAB27121.1; BAB28433.1; BAB31353.1; AAH36987.1;
Genbank nucleotide ID	NM_013765.2
Ensembl protein ID	ENSMUSP00000026420
Ensembl nucleotide ID	ENSMUSG00000025362
Gene name	40S ribosomal protein S26
Gene symbol	Rps26
Organism	Mus musculus
NCBI taxa ID	10090
Cleft type
Developmental stage
Data sources	Homology search
Reference
Functional description
Sequence	MTKKRRNNGR AKKGRGHVQP IRCTNCARCV PKDKAIKKFV IRNIVEAAAV RDISEASVFD 60 AYVLPKLYVK LHYCVSCAIH SKVVRNRSRE ARKDRTPPPR FRPAGAAPRP PPKPM 115

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation	Gene symbol	Entrez ID	UniProt ID	Cleft type	Developmental stage	Species	Evidence	Details
1:1 ortholog	RPS26		F1MB60			Bos taurus	Prediction	More>>
1:1 ortholog	RPS26		J9P4R8			Canis lupus familiaris	Prediction	More>>
1:1 ortholog		102173919	A0A452ELE6			Capra hircus	Prediction	More>>
1:1 ortholog	RPS26	100034009	F6YKH4			Equus caballus	Prediction	More>>
1:1 ortholog	RPS26	6231	P62854			Homo sapiens	Publication	More>>
1:1 ortholog	Rps26	27370	P62855			Mus musculus	Prediction	More>>
1:1 ortholog	RPS26	100037997	P49171			Sus scrofa	Prediction	More>>
1:1 ortholog	LOC100361854	100361854	D3Z8D7			Rattus norvegicus	Prediction	More>>

Identified variants/mutations related to cleft phenotype

Gene symbol	Significant Variants/SNPS	Methods	PubMed ID
RPS26	rs705704G>A	GWAS	28232668

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0003729	mRNA binding	ISO
GO:0003729	mRNA binding	IBA
GO:0003735	structural constituent of ribosome	IBA

GO:Biological Process

GO ID	GO Term	Evidence
GO:0002181	cytoplasmic translation	ISS
GO:0002181	cytoplasmic translation	ISO
GO:0033119	negative regulation of RNA splicing	ISO

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0022627	cytosolic small ribosomal subunit	ISS
GO:0022627	cytosolic small ribosomal subunit	ISO
GO:0022627	cytosolic small ribosomal subunit	IBA
GO:0042788	polysomal ribosome	ISS
GO:0042788	polysomal ribosome	ISO
GO:0098556	cytoplasmic side of rough endoplasmic reticulum membrane	ISS

Reactome Pathway

Reactome ID	Reactome Term	Evidence
R-MMU-156827	L13a-mediated translational silencing of Ceruloplasmin expression	IEA
R-MMU-1799339	SRP-dependent cotranslational protein targeting to membrane	IEA
R-MMU-392499	Metabolism of proteins	IEA
R-MMU-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	IEA
R-MMU-72312	rRNA processing	IEA
R-MMU-72613	Eukaryotic Translation Initiation	IEA
R-MMU-72649	Translation initiation complex formation	IEA
R-MMU-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	IEA
R-MMU-72689	Formation of a pool of free 40S subunits	IEA
R-MMU-72695	Formation of the ternary complex, and subsequently, the 43S complex	IEA
R-MMU-72702	Ribosomal scanning and start codon recognition	IEA
R-MMU-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	IEA
R-MMU-72737	Cap-dependent Translation Initiation	IEA
R-MMU-72766	Translation	IEA
R-MMU-8868773	rRNA processing in the nucleus and cytosol	IEA
R-MMU-8953854	Metabolism of RNA	IEA
R-MMU-927802	Nonsense-Mediated Decay (NMD)	IEA
R-MMU-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	IEA
R-MMU-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	IEA

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0963	Cytoplasm
KW-0256	Endoplasmic reticulum
KW-0597	Phosphoprotein
KW-1185	Reference proteome
KW-0687	Ribonucleoprotein
KW-0689	Ribosomal protein

Interpro

InterPro ID	InterPro Term
IPR000892	Ribosomal_S26e
IPR038551	Ribosomal_S26e_sf

PROSITE

PROSITE ID	PROSITE Term
PS00733	RIBOSOMAL_S26E

Pfam

Pfam ID	Pfam Term
PF01283	Ribosomal_S26e