Gene: Rps26

Basic information

Tag Content
Uniprot ID P62855; P02383; P70394; Q06722;
Entrez ID 27370
Genbank protein ID AAH81452.1; BAB25586.1; AAB07729.1; BAB27121.1; BAB28433.1; BAB31353.1; AAH36987.1;
Genbank nucleotide ID NM_013765.2
Ensembl protein ID ENSMUSP00000026420
Ensembl nucleotide ID ENSMUSG00000025362
Gene name 40S ribosomal protein S26
Gene symbol Rps26
Organism Mus musculus
NCBI taxa ID 10090
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MTKKRRNNGR AKKGRGHVQP IRCTNCARCV PKDKAIKKFV IRNIVEAAAV RDISEASVFD 60
AYVLPKLYVK LHYCVSCAIH SKVVRNRSRE ARKDRTPPPR FRPAGAAPRP PPKPM 115

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologRPS26F1MB60Bos taurusPredictionMore>>
1:1 orthologRPS26J9P4R8Canis lupus familiarisPredictionMore>>
1:1 ortholog102173919A0A452ELE6Capra hircusPredictionMore>>
1:1 orthologRPS26100034009F6YKH4Equus caballusPredictionMore>>
1:1 orthologRPS266231P62854Homo sapiensPublicationMore>>
1:1 orthologRps2627370P62855Mus musculusPredictionMore>>
1:1 orthologRPS26100037997P49171Sus scrofaPredictionMore>>
1:1 orthologLOC100361854100361854D3Z8D7Rattus norvegicusPredictionMore>>

Identified variants/mutations related to cleft phenotype

Gene symbol Significant Variants/SNPS Methods PubMed ID
RPS26rs705704G>AGWAS28232668

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0003729 mRNA bindingISO
GO:0003729 mRNA bindingIBA
GO:0003735 structural constituent of ribosomeIBA

GO:Biological Process

GO ID GO Term Evidence
GO:0002181 cytoplasmic translationISS
GO:0002181 cytoplasmic translationISO
GO:0033119 negative regulation of RNA splicingISO

GO:Cellular Component

GO ID GO Term Evidence
GO:0022627 cytosolic small ribosomal subunitISS
GO:0022627 cytosolic small ribosomal subunitISO
GO:0022627 cytosolic small ribosomal subunitIBA
GO:0042788 polysomal ribosomeISS
GO:0042788 polysomal ribosomeISO
GO:0098556 cytoplasmic side of rough endoplasmic reticulum membraneISS

Reactome Pathway

Reactome ID Reactome Term Evidence
R-MMU-156827 L13a-mediated translational silencing of Ceruloplasmin expressionIEA
R-MMU-1799339 SRP-dependent cotranslational protein targeting to membraneIEA
R-MMU-392499 Metabolism of proteinsIEA
R-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosolIEA
R-MMU-72312 rRNA processingIEA
R-MMU-72613 Eukaryotic Translation InitiationIEA
R-MMU-72649 Translation initiation complex formationIEA
R-MMU-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43SIEA
R-MMU-72689 Formation of a pool of free 40S subunitsIEA
R-MMU-72695 Formation of the ternary complex, and subsequently, the 43S complexIEA
R-MMU-72702 Ribosomal scanning and start codon recognitionIEA
R-MMU-72706 GTP hydrolysis and joining of the 60S ribosomal subunitIEA
R-MMU-72737 Cap-dependent Translation InitiationIEA
R-MMU-72766 TranslationIEA
R-MMU-8868773 rRNA processing in the nucleus and cytosolIEA
R-MMU-8953854 Metabolism of RNAIEA
R-MMU-927802 Nonsense-Mediated Decay (NMD)IEA
R-MMU-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)IEA
R-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)IEA

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0963 Cytoplasm
KW-0256 Endoplasmic reticulum
KW-0597 Phosphoprotein
KW-1185 Reference proteome
KW-0687 Ribonucleoprotein
KW-0689 Ribosomal protein

Interpro

InterPro ID InterPro Term
IPR000892 Ribosomal_S26e
IPR038551 Ribosomal_S26e_sf

PROSITE

PROSITE ID PROSITE Term
PS00733 RIBOSOMAL_S26E

Pfam

Pfam ID Pfam Term
PF01283 Ribosomal_S26e

Protein-protein interaction