Gene: Ermp1

Basic information

Tag Content
Uniprot ID Q3UVK0; B2RXD6; Q6ZPH9; Q8BIW0; Q8BYX7;
Entrez ID 226090
Genbank protein ID AAI51182.1; BAC98257.1; BAE23269.1; AAI51183.1; AAI57915.1; BAC38286.1; BAC29784.1;
Genbank nucleotide ID NM_001081213.1
Ensembl protein ID ENSMUSP00000124881
Ensembl nucleotide ID ENSMUSG00000046324
Gene name Endoplasmic reticulum metallopeptidase 1
Gene symbol Ermp1
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO,CLP,CLO
Developmental stage
Data sources Manually collected
Reference 25807483; 32253237;
Functional description Within the ovary, required for the organization of somatic cells and oocytes into discrete follicular structures.
Sequence
MEWSSESAAV RRHRGTAERR EGEAAASHRQ REASAQEDAK GVGRMWGKTE NGGGSRVAKT 60
ALSEARTALA LALYLLALRA LVQLSLQRLV LSRTSGLQGE FDARQARDYL EHITAIGPRT 120
TGSTENEILT VQYLLEQIKL IEAQSNSLHS ISVDIQRPTG SFSIDFLGGF TSYYDNITNV 180
VVKLEPRDGA ESAILANCHF DSVANSPGAS DDAVSCAVML EVLRVMSASP EPMQHAVVFL 240
FNGAEENVLQ ASHGFITQHP WASLIRAFIN LEAAGVGGKE LVFQTGPENP WLVQAYVSAA 300
KHPFASVVAQ EVFQSGIIPS DTDFRIYRDF GNIPGIDLAF IENGYIYHTK YDTADRILID 360
SIQRAGDNIL AVLKHLATSD TLASSSEYRH GSMVFFDVLG LLVIAYPSRV GSIINYMVVM 420
AVVLYLGKKL LRPKHRNANY MRDFLCGLGI TFISWFTSLV TVLIIAVFIS LIGQSLSWYN 480
YFYIAVCLYG TATVAKIIFI HTLAKRFYYM NASDLYLGEL FFDTSLFVHC AFLVALTYQG 540
FCSAFMSAVW VVFPLLTKLC VYKDFKKHGA QGRFVALYLL GMFIPYLYGL YLIWAVFEMF 600
TPILGRSGSE IPPDVVLASI LAVCVMILSS YFITFIYLVN STKKTILTLI LVCAVTFLLV 660
CSGAFFPYSS NPESPKPKRV FLQHVSRTFH NLEGSVVKRD SGIWINGFDY TGMSHVTPHI 720
PEINDTIRAH CEEDAPLCGF PWYLPVHFLI RKNWYLPAPE VSPRNPAHFR LVSKEKMPWD 780
SIKLTFEATG PSHMSFYVRT HKGSTLSQWS LGNGIPVTSR GGDYFVFYSH GLQASAWRFW 840
IEVQVSEEQA EGMVTVAIAA HYLSGENKRS SQLDALKKKF PDWSFPSAWV STYSLFVF 898

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologERMP1A0A452G9M4Capra hircusPredictionMore>>
1:1 orthologERMP179956Q7Z2K6Homo sapiensPredictionMore>>
1:1 orthologErmp1226090Q3UVK0CPO,CLP,CLOMus musculusPublicationMore>>
1:1 orthologERMP1464983H2QX00Pan troglodytesPredictionMore>>
1:1 orthologERMP1F1SMM0Sus scrofaPredictionMore>>
1:1 orthologErmp1F1M6W2Rattus norvegicusPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0003674 molecular_functionND
GO:0008237 metallopeptidase activityIEA
GO:0046872 metal ion bindingIEA

GO:Biological Process

GO ID GO Term Evidence
GO:0001541 ovarian follicle developmentISO
GO:0006508 proteolysisIBA

GO:Cellular Component

GO ID GO Term Evidence
GO:0005783 endoplasmic reticulumISO
GO:0005789 endoplasmic reticulum membraneIEA
GO:0016021 integral component of membraneIEA

Reactome Pathway

Reactome ID Reactome Term Evidence

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0007 Acetylation
KW-0025 Alternative splicing
KW-1015 Disulfide bond
KW-0256 Endoplasmic reticulum
KW-0325 Glycoprotein
KW-0378 Hydrolase
KW-0472 Membrane
KW-0479 Metal-binding
KW-0482 Metalloprotease
KW-0645 Protease
KW-1185 Reference proteome
KW-0812 Transmembrane
KW-1133 Transmembrane helix
KW-0862 Zinc

Interpro

InterPro ID InterPro Term
IPR007484 Peptidase_M28

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF04389 Peptidase_M28

Protein-miRNA interaction