Gene: Kifbp

Basic information

Tag Content
Uniprot ID Q6ZPU9; Q3TYD0; Q5BKR5; Q7TPE0; Q80VQ5; Q8BZE2; Q8CFS7;
Entrez ID 72320
Genbank protein ID AAH90974.1; BAC29142.1; BAE34633.1; BAC98130.1; AAH38828.1; AAH55307.1; AAH46485.1;
Genbank nucleotide ID NM_028197.2
Ensembl protein ID ENSMUSP00000065160
Ensembl nucleotide ID ENSMUSG00000036955
Gene name KIF-binding protein
Gene symbol Kifbp
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 21677750
Functional description Required for neuronal development and differentiation. Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development.
Sequence
MANAPGPEIR EKFQAALALS RVELHKNPEK EPYKSKYGAR ALLEEVRALL GPAPEDEDEP 60
AADDGPGDQA LGAGEPREAE GPGAQRALRL AVVEFHLGVN HIDTEELSAG EEHLVRCLSL 120
LRPYRLSLGC VSLYIQAQNN LGILWSEREE IETARTYLES SEALYSQYMK EIGSPPLDPT 180
EHFLPEEEKL TEQERSKRFE KVYTHNLYYL AQVYQHMEMF EKAAHYCHST LKRQLEHNAY 240
HPMEWAINAA TLSQFYINKL CFMEARHCLS AANVIFGQTG KIPATEDTPE VEGDVPELYH 300
QRKGEIARCW IKYCLTLMQN AQLSMQDNIG ELDLDKQSEL RALRKKELDE EESVRKRAVQ 360
FGTGELCDAI SAVEEKVRYL RPLDFEEARE LFLLGQHYVC EAKEFFQIDG YVTDHIEVVQ 420
DHSALFKVLS FFEADMERRC KMHKRRIAML EPLTVDLNPQ YYLLVSRQIQ FEIAHAYYDM 480
MDLKVAIADK LRDPDSHIVK KINSLNKSAL KYYQLFLDSL RDPNKVFPEH IGEDVLRPAM 540
LAKFRVARLY GKIITADPKK ELENLATSLE HYKFIVDYCE THPEAAQEIE VELELSKEMV 600
SLLPTKMERF RAKMALT 617

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologKIFBP527433Q3SYS9Bos taurusPredictionMore>>
1:1 orthologKIFBP479232E2QTI7Canis lupus familiarisPredictionMore>>
1:1 orthologKIFBPA0A452DK96Capra hircusPredictionMore>>
1:1 orthologKIFBP100063227F7D3N0Equus caballusPredictionMore>>
1:1 orthologKIFBPA0A1B0GUA3Homo sapiensPredictionMore>>
1:1 orthologKifbp72320Q6ZPU9CPOMus musculusPublicationMore>>
1:1 orthologKIFBPH2R3T2Pan troglodytesPredictionMore>>
1:1 orthologKIFBP100151916F1SUG6Sus scrofaPredictionMore>>
1:1 orthologKif1bp606294G3V614Rattus norvegicusPredictionMore>>
1:1 orthologkifbp100002194B8A5I1Danio rerioPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0019894 kinesin bindingISO

GO:Biological Process

GO ID GO Term Evidence
GO:0001701 in utero embryonic developmentIMP
GO:0006839 mitochondrial transportISS
GO:0006839 mitochondrial transportISO
GO:0007399 nervous system developmentIEA
GO:0030154 cell differentiationIEA

GO:Cellular Component

GO ID GO Term Evidence
GO:0005739 mitochondrionISS
GO:0005739 mitochondrionISO
GO:0005856 cytoskeletonIEA

Reactome Pathway

Reactome ID Reactome Term Evidence

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0025 Alternative splicing
KW-0963 Cytoplasm
KW-0206 Cytoskeleton
KW-0217 Developmental protein
KW-0221 Differentiation
KW-0524 Neurogenesis
KW-0597 Phosphoprotein
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR022083 KBP
IPR011990 TPR-like_helical_dom_sf

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF12309 KBP_C