| Tag | Content |
|---|---|
| Uniprot ID | Q7TSH4; Q6A072; |
| Entrez ID | 101565 |
| Genbank protein ID | BAD32224.1; AAH53103.1; |
| Genbank nucleotide ID | NM_182995.1 |
| Ensembl protein ID | ENSMUSP00000102167; ENSMUSP00000038881; |
| Ensembl nucleotide ID | ENSMUSG00000033904 |
| Gene name | Centriolar coiled-coil protein of 110 kDa |
| Gene symbol | Ccp110 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 26965371 |
| Functional description | Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:23141541). Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (PubMed:26965371). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (By similarity). |
| Sequence | MEEYEEFCEK ALGRAQEASL STGSFLPAQA ESVSLIRFHG VAVLSPLLTI EKRKKIQEEK 60 QKALDVQSRK QANRKKALLT RVQEILENVQ VRKAPNASDF DQWATETIYS NPEVTDLNVP 120 VRVPNSLPSP TEHCTSVKLE KITGLLPVNN EDQQTPKRVG LPGDSEVSGS LRQCESPESR 180 QAEDGAALRL SSASPQETII SDVLGKEEQD PSCLAEVTPD PYIMSLQNLM KRSKEYVERE 240 LSSRSLRNSL KRSVNETHSD RENDAAKASD CVKEKAPPMP IGRHCGSAIP DKPSLNKSNV 300 LLQGASQASS MGTAGLASFS KIDLPAGAAP PAAPDAGSDF TVIPTFVTEN KVKSLKGPYA 360 KLPSPEPSMS PTMHRRHSRS ASACQILINN PVNACELSPK GKEEAVDRTA PAAAETTNES 420 ETVPKSPTDL TGVCSSNVSA TKITSESTRE MVVGKPSQRQ QALGAHLGNN VTVERSAMEG 480 PFIADDRGAQ KVDGTCMAVP KLHELQPSSQ CVSSQTLEDV CELKSASLLA KNSCNLQMEL 540 NKSYDVKHPS PLLTQTQTSR QQMDTPPVFR GNEQFVDNSF EKVKRRLDLD VDSLQKENCP 600 YIITAGVAEQ ERDRLLERRY PKGFVHINKN KMLETSPKEG QELLKSKMLA FEEMRKRLEE 660 QHAQQLSLLI AEQEREQEQL QKEIEEQEKM LKEKAVTTDV SDLNSALEWR QRTDSALLET 720 MLSQVDSLQT SNNSGFITSA LQYSFGSAGE APFYLWGSLT SGVTRVSGTR PCGRAQAKWS 780 QVFNPEIHAK FNKITAVAKG FLTRKLMQTD KLKQLRQTVK DTMEFIRSFQ SEAPLKRGVV 840 SAQDASLQER VLAQLRAALY GIHDIFFVMD AAERMSILHH DREARKEKLL RQMDKMKSPR 900 VALSVATQKS LDRKKFMKVA EMGMPNKKFL LKQNPSETRV LQPNQGQNAP VHRLLSRQGT 960 PKTSVKGVVQ NRQKPSQSRV PNRAPVSGAY AGKTQRKRPN VATI 1004 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
