| Tag | Content |
|---|---|
| Uniprot ID | Q8BWR8; Q9DBN2; |
| Entrez ID | 52428 |
| Genbank protein ID | BAC34127.1; BAB23615.1; |
| Genbank nucleotide ID | NM_027897.4 |
| Ensembl protein ID | ENSMUSP00000032705; ENSMUSP00000082692; |
| Ensembl nucleotide ID | ENSMUSG00000030494 |
| Gene name | Rhophilin-2 |
| Gene symbol | Rhpn2 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity (By similarity). |
| Sequence | MTDTLLPAAP QPLEKEGDDY FRKGCNPLAQ TGRSKLQNQR AALNQQILKA VRMRTGAENL 60 LKVATNQKVR EQVRLELSFV NSDLQMLKEE LEGLNISVGV YQGTEEAFTI PLIPLGLKET 120 KEVDFSIVFK DFILEHYSED SYLYEDDIAD LMDLRQACRT PSRDEAGVEL LMSYFIQLGF 180 VESRFFPPTR HMGLLFTWYD SFTGVPVSQQ TLLLEKASVL FNIGALYTQI GTRCNRQTQA 240 GLESAVDAFQ RAAGVLNYLK ETFTHTPSYD MSPAMLSVLV KMMLAQAQES VFEKVCLPGI 300 QNEFFVLVKV AQEAAKVAEA YRQLHAAMSQ EPVKENIPYS WASVAYVKAY HYGALAHYFA 360 ATLLIDHQLK PGADEDHQEK CLSQLYDRMP EGMTPLATLK NAGQRVLLGK GHLHRAIGFH 420 EESLREANLC KKLRDIQVLR DVLSAAHQRT QLKHTQHRED DDLLNLIDAP DVLPKTEREV 480 KITFPDFSKV TVTDFFQKLG PLSVFSASKR WSPPRGIHFT VEEGDLGFTL RGNTPVQVHF 540 LDPHCSASLA GAKEGDYIVS IQGVDCKWLT VSEVMKLLKS FGGEEVEMKV VSLLDSTSSM 600 HNKCATYSVG MQKTYSMICL SMDDDDKADK TKKISKKLSF LSWGTSKNRQ KSASTLCLPE 660 VGLARSQNKK KLPTPFSLLN SDSSLY 686 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | RHPN2 | 102189513 | A0A452E2S5 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | RHPN2 | 85415 | Q8IUC4 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Rhpn2 | 52428 | Q8BWR8 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | A0A4X1TSG5 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | Rhpn2 | 308516 | D4A8N7 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | rhpn2 | F1QEF4 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0003674 | molecular_function | ND |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0007165 | signal transduction | IEA |
| GO:0008150 | biological_process | ND |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0048471 | perinuclear region of cytoplasm | IEA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-194315 | Signaling by Rho GTPases | IEA |
| R-MMU-195258 | RHO GTPase Effectors | IEA |
| R-MMU-5666185 | RHO GTPases Activate Rhotekin and Rhophilins | IEA |