Gene: Prss35

Basic information

Tag Content
Uniprot ID Q8C0F9; Q8C0D6; Q8C0L5;
Entrez ID 244954
Genbank protein ID ABB46197.1; BAC27073.1; BAC27491.1; AAH75675.1; BAC27392.1;
Genbank nucleotide ID NM_178738.3; XM_006511172.3; XM_006511171.3; XM_006511170.3;
Ensembl protein ID ENSMUSP00000137445; ENSMUSP00000035271;
Ensembl nucleotide ID ENSMUSG00000033491
Gene name Inactive serine protease 35
Gene symbol Prss35
Organism Mus musculus
NCBI taxa ID 10090
Cleft type
Developmental stage E12.0, E13.0, E14.0, E14.5
Data sources Homology search
Reference
Functional description
Sequence
MENTLLWLVI LIPGWALSDG SETELDFTWH LSRIPQVVSE NTIHLASPTF QADAGVVKAT 60
VCGIECQEEL PAPSLSQLEE SLSYETIFEN GTRTLTRVKV QGLVLEPTRN SSVKGAHPRR 120
RRQVYGTDSR FSILDKRFAT NFPFNTAVKL STGCSGTLVS PNHVLTAAHC VHDGKDYVKG 180
SKKLRVGVLK MRNKGGRKKR RGSKRSRREA ESAGQSQAHL RESTTQRPGK KSRRGPRVTQ 240
GRPSFQWTRV KSTHIPKGWV RGENGGLALD YDYALLELKR AHKQQHMELG VSPTITKLPG 300
GRIHFSGFDN DRDEQLVYRF CSVSEESNDL LYQYCDAEAG STGSGIYLRL KEPGQKNWKR 360
KIVAVYSGHQ WVDVHGVQKD YNVAVRITPL KYAQICLWIH GNAANCAYG 409

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression during embryonic days (E11.5~E18.5) ~ adult days (Ps) in the lip and palate tissues. (X-axis: days, Y-axis: tissues)

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Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologPRSS35614940Q5E9X7Bos taurusPredictionMore>>
1:1 orthologPRSS35102177164A0A452E812Capra hircusPredictionMore>>
1:1 orthologPRSS35100065435F6X7M4Equus caballusPredictionMore>>
1:1 orthologPRSS35167681Q8N3Z0Homo sapiensPublicationMore>>
1:1 orthologPrss35244954Q8C0F9E12.0, E13.0, E14.0, E14.5Mus musculusPredictionMore>>
1:1 orthologPRSS35472062H2QTC3Pan troglodytesPredictionMore>>
1:1 orthologPRSS35F1RQM7Sus scrofaPredictionMore>>
1:1 orthologPRSS35100355702G1TSZ4Oryctolagus cuniculusPredictionMore>>
1:1 orthologPrss35315866F1LLW4Rattus norvegicusPredictionMore>>

Identified variants/mutations related to cleft phenotype

Gene symbol Significant Variants/SNPS Methods PubMed ID
PRSS35rs512140*AGenotyping26602496

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence

GO:Biological Process

GO ID GO Term Evidence

GO:Cellular Component

GO ID GO Term Evidence
GO:0005576 extracellular regionIEA
GO:0005739 mitochondrionHDA

Reactome Pathway

Reactome ID Reactome Term Evidence

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1015 Disulfide bond
KW-0325 Glycoprotein
KW-1185 Reference proteome
KW-0964 Secreted
KW-0721 Serine protease homolog
KW-0732 Signal

Interpro

InterPro ID InterPro Term
IPR009003 Peptidase_S1_PA
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS

PROSITE

PROSITE ID PROSITE Term
PS00134 TRYPSIN_HIS

Pfam

Pfam ID Pfam Term
PF00089 Trypsin

Protein-miRNA interaction