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Gene Information
Gene ID:10006
Full Name:abl-interactor 1
Organism:Homo sapiens (Human)
Genetic Location:10p11.2
Physical Location:27075530-27189964 on NC_000010.9, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:SSH3BP1
Original ID2:R34245
Dataset Information
Tissue:SH-SY5Y neuroblastoma cells
Phenotype:Ethanol response
Publication:Thibault et al. Mol Pharmacol. (2000) Expression profiling of neural cells reveals specific patterns of ethanol-responsive gene expression. PubMed
Summary:We used oligonucleotide arrays to study nearly 6000 genes in human SH-SY5Y neuroblastoma cells exposed to chronic ethanol. A set of 42 genes had consistently increased or decreased mRNA abundance after 3 days of ethanol treatment.
Gene Information
Original ID1:Hs.508148
Note:"Class II, up-regulated gene"
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001012750.1NP_001012768.1NC_000010.9 range: 27075530..27189964, complement
NM_001012751.1NP_001012769.1NC_000010.9 range: 27075530..27189964, complement
NM_001012752.1NP_001012770.1NC_000010.9 range: 27075530..27189964, complement
NM_005470.2NP_005461.2NC_000010.9 range: 27075530..27189964, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005622intracellularCellular ComponentIDA (17101133)
GO:0030054cell junctionCellular ComponentIEA
GO:0030027lamellipodiumCellular ComponentIDA (17101133)
GO:0019717synaptosomeCellular ComponentIEA
GO:0045202synapseCellular ComponentIEA
GO:0005856cytoskeletonCellular ComponentIEA
GO:0005829cytosolCellular ComponentTAS (9010225)
GO:0005783endoplasmic reticulumCellular ComponentTAS (9593709)
GO:0005737cytoplasmCellular ComponentIEA
GO:0005634nucleusCellular ComponentIEA
GO:0005625soluble fractionCellular ComponentTAS (9010225)
GO:0008092cytoskeletal protein bindingMolecular FunctionTAS (9593709)
GO:0008285negative regulation of cell proliferationBiological ProcessTAS (9010225)
GO:0018108peptidyl-tyrosine phosphorylationBiological ProcessIDA (17101133)
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayBiological ProcessTAS (9010225)
Other Database Cross Links
NCBI Entrez Gene:10006
HuGE Navigator:10006