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Gene Information
Gene ID:10400
Symbol:PEMT
Full Name:phosphatidylethanolamine N-methyltransferase
Alias:MGC2483|PEAMT|PEMPT|PEMT2|PNMT
Organism:Homo sapiens (Human)
Chromosome:17
Genetic Location:17p11.2
Physical Location:17349601-17435718 on NC_000017.9, complement
Gene Type:protein-coding
Orthologs:This gene has Mouse: 18618 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hs.287717
Note:"Class II, up-regulated gene"
Dataset Information
Name:16292326
Method:Microarray
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.
Gene Information
Original ID1:PEMT
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Linkage Dataset
MarkerLODP valueLocation (bp)
D17S1857  16355942
Region:14355942-18355942
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Name:15211641
Method:Linkage
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_007169.2NP_009100.2NC_000017.9 range: 17349601..17435718, complement
NM_148172.1NP_680477.1NC_000017.9 range: 17349601..17435718, complement
NM_148173.1NP_680478.1NC_000017.9 range: 17349601..17435718, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0031966mitochondrial membraneCellular ComponentIEA
GO:0005739mitochondrionCellular ComponentIEA
GO:0005783endoplasmic reticulumCellular ComponentIEA
GO:0005789endoplasmic reticulum membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0016740transferase activityMolecular FunctionIEA
GO:0008170N-methyltransferase activityMolecular FunctionIEA
GO:0004608phosphatidylethanolamine N-methyltransferase activityMolecular FunctionTAS (9989271)
GO:0008283cell proliferationBiological ProcessTAS (9989271)
GO:0008654phospholipid biosynthetic processBiological ProcessIEA
GO:0006656phosphatidylcholine biosynthetic processBiological ProcessTAS (9989271)
GO:0006644phospholipid metabolic processBiological ProcessIEA
GO:0006629lipid metabolic processBiological ProcessTAS (9989271)
Other Database Cross Links
NCBI Entrez Gene:10400
HGNC:8830
Ensembl:ENSG00000133027
MIM:602391
HPRD:03862
HuGE Navigator:10400
dbSNP:PEMT
GeneCard:PEMT
AceView:PEMT