ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CLCN3

Full Name:

chloride channel 3

Alias:

CLC3|ClC-3

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

4q33

Physical Location:

170778296-170878731 on NC_000004.10

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 12725 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.481186
Note:		"Class II, down-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000139	Golgi membrane	Cellular Component	IEA
GO:0031902	late endosome membrane	Cellular Component	IEA
GO:0031901	early endosome membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	TAS (12471024)
GO:0012506	vesicle membrane	Cellular Component	ISS
GO:0012506	vesicle membrane	Cellular Component	IDA (12471024)
GO:0009986	cell surface	Cellular Component	NAS (12471024)
GO:0005886	plasma membrane	Cellular Component	IEA
GO:0005794	Golgi apparatus	Cellular Component	ISS
GO:0005794	Golgi apparatus	Cellular Component	IDA (12471024)
GO:0030165	PDZ domain binding	Molecular Function	ISS
GO:0005247	voltage-gated chloride channel activity	Molecular Function	TAS (7665160)
GO:0031404	chloride ion binding	Molecular Function	IEA
GO:0042803	protein homodimerization activity	Molecular Function	NAS (12471024)
GO:0030165	PDZ domain binding	Molecular Function	IDA (12471024)
GO:0005515	protein binding	Molecular Function	IPI (12471024)
GO:0046982	protein heterodimerization activity	Molecular Function	IDA (12471024)
GO:0046982	protein heterodimerization activity	Molecular Function	ISS
GO:0005244	voltage-gated ion channel activity	Molecular Function	IEA
GO:0006811	ion transport	Biological Process	IEA
GO:0006885	regulation of pH	Biological Process	TAS (12471024)
GO:0006821	chloride transport	Biological Process	IEA
GO:0048388	endosomal lumen acidification	Biological Process	TAS (12471024)