ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Clcn3

Full Name:

chloride channel 3

Alias:

Clc3

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

8 B3.1|8 32.2 cM

Physical Location:

63389185-63462096 on NC_000074.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1182 Symbol (Name): CLCN3 (chloride channel 3)

Ortholog Status:

The human GeneID 1182 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Clcn3
Original ID2:		AI849432

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Caws3/Alcw6	Chronic Alcohol Withdrawal	8		16-43 (cM)	3.5	0.0003	Significant	PARC

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	RCA (12466851)
GO:0016020	membrane	Cellular Component	IEA
GO:0005768	endosome	Cellular Component	IEA
GO:0005216	ion channel activity	Molecular Function	IEA
GO:0031404	chloride ion binding	Molecular Function	IEA
GO:0005254	chloride channel activity	Molecular Function	IEA
GO:0005247	voltage-gated chloride channel activity	Molecular Function	IEA
GO:0005244	voltage-gated ion channel activity	Molecular Function	IEA
GO:0006811	ion transport	Biological Process	IEA
GO:0006821	chloride transport	Biological Process	IEA
GO:0006810	transport	Biological Process	IEA