ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Bid

Full Name:

BH3 interacting domain death agonist

Alias:

2700049M22Rik|AI875481|AU022477

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

6 F1|6 54.0 cM

Physical Location:

120843136-120866837 on NC_000072.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 637 Symbol (Name): BID (BH3 interacting domain death agonist)

Ortholog Status:

The human GeneID 637 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Bid
Original ID2:		U75506

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_007544.3	NP_031570.2	NC_000072.5 range: 120843136..120866837, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005739	mitochondrion	Cellular Component	IEA
GO:0005829	cytosol	Cellular Component	IDA (11980919)
GO:0016020	membrane	Cellular Component	IEA
GO:0005515	protein binding	Molecular Function	IPI (15661737)
GO:0006915	apoptosis	Biological Process	IDA (12011074)
GO:0042981	regulation of apoptosis	Biological Process	RCA (12819136)
GO:0043065	positive regulation of apoptosis	Biological Process	IEA