ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

BID

Full Name:

BH3 interacting domain death agonist

Alias:

FP497|MGC15319|MGC42355

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

22q11.1

Physical Location:

16596905-16637257 on NC_000022.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 12122 Rat: 64625 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

BID

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Linkage Dataset

Marker

LOD

P value

Location (bp)

D22S420

2.04

0.0011

16239281

D22S1638

2.05

0.0011

17375064

Region:		16239281-17375064
Phenotype:		TOLMX (tolerance/maximum drinking)
Name:		17067344
Method:		Linkage
Publication:		Kuo et al. Alcohol Clin Exp Res. (2006) Identification of susceptibility loci for alcohol-related traits in the Irish Affected Sib Pair Study of Alcohol Dependence. PubMed
Summary:		A 4-cM dense whole-genome linkage study was conducted in the Irish Affected Sib Pair Study of Alcohol Dependence. Probands, affected siblings, and parents were evaluated by structured interview. Variance component linkage analysis was applied to data from 485 families for 5 measures: initial sensitivity and tolerance (based on scales from the self-report of the effects of ethanol; maximum drinks within 24 hours, an empirically derived factor score based on withdrawal symptoms, and age at onset of alcohol dependence.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005741	mitochondrial outer membrane	Cellular Component	EXP (9727492\|10950869\|12624108)
GO:0005829	cytosol	Cellular Component	TAS (8918887)
GO:0005829	cytosol	Cellular Component	EXP (10629050\|11099414\|11114298\|12804595)
GO:0016020	membrane	Cellular Component	IEA
GO:0005739	mitochondrion	Cellular Component	TAS (9727491)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005624	membrane fraction	Cellular Component	TAS (8918887)
GO:0005515	protein binding	Molecular Function	ISS
GO:0005123	death receptor binding	Molecular Function	TAS (8918887)
GO:0008633	activation of pro-apoptotic gene products	Biological Process	EXP (15231831)
GO:0008625	induction of apoptosis via death domain receptors	Biological Process	TAS (9727491)
GO:0001836	release of cytochrome c from mitochondria	Biological Process	IDA (17052454)
GO:0051402	neuron apoptosis	Biological Process	TAS (16167175)