ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Bid

Full Name:

BH3 interacting domain death agonist

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

4q42

Physical Location:

157296382-157318480 on NC_005103.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 637 Symbol (Name): BID (BH3 interacting domain death agonist)

Ortholog Status:

The human GeneID 637 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Bid
Fold Change:		-1.14
P Value:		0.003
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_022684.1	NP_073175.1	NC_005103.2 range: 157296382..157318480, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005739	mitochondrion	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0031966	mitochondrial membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005515	protein binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (15004018)
GO:0005515	protein binding	Molecular Function	ISS
GO:0006915	apoptosis	Biological Process	ISS
GO:0006915	apoptosis	Biological Process	IEA
GO:0001836	release of cytochrome c from mitochondria	Biological Process	ISS
GO:0043065	positive regulation of apoptosis	Biological Process	IEA