ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Car2

Full Name:

carbonic anhydrase 2

Alias:

AI131712|CAII|Car-2|Ltw-5|Lvtw-5

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

3 A1|3 10.5 cM

Physical Location:

14886724-14900768 on NC_000069.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 760 Symbol (Name): CA2 (carbonic anhydrase II)

Ortholog Status:

The human GeneID 760 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Car2
Original ID2:		AV230631

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_009801.4	NP_033931.4	NC_000069.5 range: 14886724..14900768

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0004089	carbonate dehydratase activity	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0016829	lyase activity	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0002009	morphogenesis of an epithelium	Biological Process	IMP (16217040)
GO:0006730	one-carbon compound metabolic process	Biological Process	IEA
GO:0015670	carbon dioxide transport	Biological Process	IMP (16217040)
GO:0046903	secretion	Biological Process	IMP (16217040)