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Gene Information
Gene ID:12349
Full Name:carbonic anhydrase 2
Organism:Mus musculus (Mouse)
Genetic Location:3 A1|3 10.5 cM
Physical Location:14886724-14900768 on NC_000069.5
Gene Type:protein-coding
Human Ortholog:GeneID: 760    Symbol (Name): CA2 (carbonic anhydrase II)
Ortholog Status:The human GeneID 760 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Car2
Original ID2:AV230631
Dataset Information
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_009801.4NP_033931.4NC_000069.5 range: 14886724..14900768
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIEA
GO:0004089carbonate dehydratase activityMolecular FunctionIEA
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0016829lyase activityMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0002009morphogenesis of an epitheliumBiological ProcessIMP (16217040)
GO:0006730one-carbon compound metabolic processBiological ProcessIEA
GO:0015670carbon dioxide transportBiological ProcessIMP (16217040)
GO:0046903secretionBiological ProcessIMP (16217040)
Other Database Cross Links
NCBI Entrez Gene:12349