ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Cpe

Full Name:

carboxypeptidase E

Alias:

CPH|Cph-1|Cph1|MGC7101|R74677|fat

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

8 B3.1|8 32.6 cM

Physical Location:

67071338-67171836 on NC_000074.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1363 Symbol (Name): CPE (carboxypeptidase E)

Ortholog Status:

The human GeneID 1363 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Cpe
Original ID2:		X61232

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Caws3/Alcw6	Chronic Alcohol Withdrawal	8		16-43 (cM)	3.5	0.0003	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_013494.3	NP_038522.2	NC_000074.5 range: 67071338..67171836, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0004180	carboxypeptidase activity	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0008237	metallopeptidase activity	Molecular Function	IEA
GO:0008233	peptidase activity	Molecular Function	IEA
GO:0004183	carboxypeptidase E activity	Molecular Function	IMP (7663508)
GO:0004182	carboxypeptidase A activity	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0006508	proteolysis	Biological Process	IEA
GO:0030070	insulin processing	Biological Process	IMP (7663508)