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Gene Information
Gene ID:12876
Symbol:Cpe
Full Name:carboxypeptidase E
Alias:CPH|Cph-1|Cph1|MGC7101|R74677|fat
Organism:Mus musculus (Mouse)
Chromosome:8
Genetic Location:8 B3.1|8 32.6 cM
Physical Location:67071338-67171836 on NC_000074.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 1363    Symbol (Name): CPE (carboxypeptidase E)
Ortholog Status:The human GeneID 1363 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Cpe
Original ID2:X61232
Dataset Information
Name:15745951
Method:Microarray
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
QTL Information
QTLPhenotypeChrPeak (cM)LODP ValueRangeStatusQTL Link
Caws3/Alcw6Chronic Alcohol Withdrawal8 16-43 (cM)3.50.0003SignificantPARC
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_013494.3NP_038522.2NC_000074.5 range: 67071338..67171836, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005576extracellular regionCellular ComponentIEA
GO:0005615extracellular spaceCellular ComponentRCA (12466851)
GO:0004180carboxypeptidase activityMolecular FunctionIEA
GO:0016787hydrolase activityMolecular FunctionIEA
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0008237metallopeptidase activityMolecular FunctionIEA
GO:0008233peptidase activityMolecular FunctionIEA
GO:0004183carboxypeptidase E activityMolecular FunctionIMP (7663508)
GO:0004182carboxypeptidase A activityMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0006508proteolysisBiological ProcessIEA
GO:0030070insulin processingBiological ProcessIMP (7663508)
Other Database Cross Links
NCBI Entrez Gene:12876
MGI:
Ensembl:ENSMUSG00000037852
dbSNP:Cpe
AceView:Cpe