ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CPE

Full Name:

carboxypeptidase E

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

4q32.3

Physical Location:

166519537-166638925 on NC_000004.10

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 12876 Rat: 25669 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		CPE
Original ID2:		X51405

Dataset Information

Name:		11093800
Method:		Microarray
Tissue:		SH-SY5Y neuroblastoma cells
Phenotype:		Ethanol response
Publication:		Thibault et al. Mol Pharmacol. (2000) Expression profiling of neural cells reveals specific patterns of ethanol-responsive gene expression. PubMed
Summary:		We used oligonucleotide arrays to study nearly 6000 genes in human SH-SY5Y neuroblastoma cells exposed to chronic ethanol. A set of 42 genes had consistently increased or decreased mRNA abundance after 3 days of ethanol treatment.

Gene Information

Original ID1:

X51405

Dataset Information

Name:		12065639
Method:		Microarray
Tissue:		Frontal and motor cortices
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Mayfield et al. J Neurochem. (2002) Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. PubMed
Summary:		We used cDNA microarrays to analyze expression of approximately 10 000 genes in the frontal and motor cortices of three groups of chronic alcoholic and matched control cases. Fluorescent intensity ratios of 1.4-fold or greater in either direction (representing the 99% confidence interval) were used to indicate differentially expressed genes.

Gene Information

Original ID1:

CPE

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene SNP Information

Association Dataset

Name:		16894614
Method:		Association
Publication:		Johnson et al. Am J Med Genet B Neuropsychiatr Genet. (2006) Pooled association genome scanning for alcohol dependence using 104,268 SNPs: validation and use to identify alcoholism vulnerability loci in unrelated individuals from the collaborative study on the genetics of alcoholism. PubMed
Summary:		Association genome scanning can identify markers for the allelic variants that contribute to vulnerability to complex disorders, including alcohol dependence. To improve the power and feasibility of this approach, we report validation of 100k microarray-based allelic frequency assessments in pooled DNA samples. We then use this approach with unrelated alcohol-dependent versus control individuals sampled from pedigrees collected by the Collaborative Study on the Genetics of Alcoholism (COGA). Allele frequency differences between alcohol-dependent and control individuals are assessed in quadruplicate at 104,268 autosomal SNPs in pooled samples. One hundred eighty-eight SNPs provide (1) the largest allele frequency differences between dependent versus control individuals; (2) t values 3 for these differences; and (3) clustering, so that 51 relatively small chromosomal regions contain at least three SNPs that satisfy criteria 1 and 2 above (Monte Carlo P = 0.00034).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001873.2	NP_001864.1	NC_000004.10 range: 166519537..166638925

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005886	plasma membrane	Cellular Component	TAS (9019408)
GO:0004180	carboxypeptidase activity	Molecular Function	TAS (9019408)
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0008237	metallopeptidase activity	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0004183	carboxypeptidase E activity	Molecular Function	IEA
GO:0004182	carboxypeptidase A activity	Molecular Function	IEA
GO:0006464	protein modification process	Biological Process	NAS (2334405)
GO:0007218	neuropeptide signaling pathway	Biological Process	NAS (2334405)
GO:0008152	metabolic process	Biological Process	TAS (7663508)
GO:0006508	proteolysis	Biological Process	IEA